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Original Paper

Free Access

Serum Brain-Derived Neurotrophic Factor in Euthymic Bipolar Patients on Prophylactic Lithium Therapy

Suwalska A.a · Sobieska M.b · Rybakowski J.K.a

Author affiliations

Departments of aAdult Psychiatry and bPhysiotherapy, Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poznan, Poland

Corresponding Author

Prof. Janusz K. Rybakowski

Department of Adult Psychiatry, Poznan University of Medical Sciences

ul. Szpitalna 27/33

PL–60-572 Poznan (Poland)

Tel. +48 61 847 5087, Fax +48 61 848 0392, E-Mail rybakows@wlkp.top.pl

Related Articles for ""

Neuropsychobiology 2010;62:229–234

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Aim: The aim of the study was to evaluate serum brain-derived neurotrophic factor (BDNF) levels in a group of euthymic bipolar patients on long-term prophylactic lithium treatment and to delineate putative relationships between lithium efficacy and BDNF concentrations. Methods: 141 euthymic bipolar patients (51 male, 90 female) on long-term lithium treatment were studied. Three categories of prophylactic lithium response were delineated: excellent lithium responders (ER; 30 patients), partial lithium responders (PR; 61 patients) and lithium nonresponders (NR; 50 patients). The control group consisted of 75 age- and gender-matched healthy subjects. Results: The lithium-treated patients as a whole group had lower BDNF levels compared to the healthy controls. However, after breaking down the patients into ER, PR and NR, it appeared that only NR had significantly lower BDNF levels compared with the healthy control subjects. No association between the age of the patients, duration of bipolar illness, and serum lithium and BDNF levels was found. Conclusion: The results point to a relationship between lithium prophylactic efficacy and plasma BDNF levels in euthymic bipolar patients where lithium NR had reduced BDNF levels. These findings suggest that serum BDNF is associated with lithium efficacy in bipolar disorder.

© 2010 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 28, 2009
Accepted: March 16, 2010
Published online: August 14, 2010
Issue release date: October 2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

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