Oncology
Clinical Translational Research
Cisplatin Application in Pregnancy: First in vivo Analysis of 7 PatientsMarnitz S.a · Köhler C.b · Oppelt P.d · Schmittel A.c · Favero G.b · Hasenbein K.b · Schneider A.b · Markman M.eaDepartment of Radiooncology, Campus CCM and CVK, bDepartment of Gynecology, Campus CCM, and cDepartment of Hematooncology, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany; dDepartment of Gynecology, General Hospital Linz, Linz, Austria; eDepartment of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Tex., USA
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Oncology 2010;79:72–77
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Article / Publication Details
First-Page Preview
Received: July 14, 2010
Accepted: July 14, 2010
Published online: November 12, 2010
Issue release date: December 2010
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
Abstract
Cervical cancer in pregnancy is an oncologic challenge. Empirical cisplatin is recommended to prevent cancer progression until fetal maturity. Seven patients with cervical cancer in the second trimester decided to delay delivery together with neoadjuvant chemotherapy. After 2–4 cycles, caesarean section and radical hysterectomy were performed above 32 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood and amniotic fluid were taken. All patients delivered healthy babies. Cisplatin concentrations in umbilical cord and amniotic fluid were 31–65 and 13–42% of the maternal blood, respectively. This is the first series on in vivo cisplatin concentration in the fetomaternal compartment.
© 2010 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Received: July 14, 2010
Accepted: July 14, 2010
Published online: November 12, 2010
Issue release date: December 2010
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1
ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)
For additional information: https://www.karger.com/OCL
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