European Surgical Research

Original Paper

Annexin-1 Downregulation Is Associated with Clinical Outcome in Chinese Patients with Hilar Cholangiocarcinoma

Wang D.a · Zhang H.b · Fang Z.c · Yu G.d

Author affiliations

aDepartment of General Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao, bDepartment of General Surgery, Huashan Hospital, cDepartment of Surgery, Eastern Hepatobiliary Hospital, and dDepartment of Medical Oncology, Changzheng Hospital, Shanghai, PR China

Keywords: CholangiocarcinomaTissue microarrayImmunohistochemistryAnnexin A1Survival analysis

Related Articles for ""
Eur Surg Res 2010;45:151–157
https://doi.org/10.1159/000320237

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 20, 2010
Accepted: August 16, 2010
Published online: October 06, 2010
Issue release date: December 2010

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Aims: Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and has been implicated in regulating inflammatory responses, cell proliferation and apoptosis. The evidence of its importance in carcinogenesis increased rapidly. However, the status of ANXA1 in hilar cholangiocarcinoma remains unclear. Here, we detected ANXA1 expression and determined its clinical significance in Chinese patients with hilar cholangiocarcinoma. Methods: Tissue microarray blocks containing tumor specimens obtained from 61 patients were constructed. Expression of ANXA1 in these specimens was analyzed using immunohistochemical studies. Results: ANXA1 expression was observed in 27 cases (44.3%). Loss of ANXA1 expression was significantly associated with lymph node metastases and histopathologic grade. ANXA1 expression has a significant inverse correlation with recurrence and poor survival in univariate analyses.Multivariate analyses revealed that loss of ANXA1 expression was an independent predictor for future recurrence and overall survival in patients with cholangiocarcinoma. Conclusions: Decreased expression of ANXA1 is a common event in human hilar cholangiocarcinoma and is significantly correlated with the poor outcome of patients with cholangiocarcinoma, suggesting a potential role of ANXA1 in cancer development and progression.

© 2010 S. Karger AG, Basel



Related Articles:

References

  1. Ito F, Cho CS, Rikkers LF, Weber SM: Hilar cholangiocarcinoma: current management. Ann Surg 2009;250:210–218.
    External Resources
  2. Hirano S, Kondo S, Tanaka E, Shichinohe T, Tsuchikawa T, Kato K, Matsumoto J, Kawasaki R: Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortality. J Hepatobiliary Pancreat Sci 2010;17:455–462.
    External Resources
  3. Goltz JP, Kenn W, Hahn D, Ritter CO: Hilar cholangiocarcinoma (Klatskin’s tumor): up-to-date radiologic diagnosis, intervention and treatment possibilities (in German). Dtsch Med Wochenschr 2009;134:985–988.
    External Resources
  4. Zong GQ, Liu XS, Wang F, Gong CH: Surgical treatment result of hilar cholangiocarcinoma: report of 84 patients (in Chinese). Zhonghua Zhong Liu Za Zhi 2007;29:312–315.
    External Resources
  5. Lim LH, Pervaiz S: Annexin 1: the new face of an old molecule. FASEB J 2007;21:968–975.
    External Resources
  6. Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L, Murota M, Tani J, Kato K, Miyoshi H, Deguchi A, Himoto T, Usuki H, Wakabayashi H, Izuishi K, Suzuki Y, Iwama H, Deguchi K, Uchida N, Sabet EA, Arafa UA, Hassan AT, El-Sayed AA, Masaki T: Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma. Int J Oncol 2008;33:1157–1163.
    External Resources
  7. Bai XF, Ni XG, Zhao P, Liu SM, Wang HX, Guo B, Zhou LP, Liu F, Zhang JS, Wang K, Xie YQ, Shao YF, Zhao XH: Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol 2004;10:1466–1470.
    External Resources
  8. Masaki T, Tokuda M, Ohnishi M, Watanabe S, Fujimura T, Miyamoto K, Itano T, Matsui H, Arima K, Shirai M, Maeba T, Sogawa K, Konishi R, Taniguchi K, Hatanaka Y, Hatase O, Nishioka M: Enhanced expression of the protein kinase substrate annexin in human hepatocellular carcinoma. Hepatology 1996;24:72–81.
    External Resources
  9. Johnson MD, Kamso-Pratt J, Pepinsky RB, Whetsell WO Jr: Lipocortin-1 immunoreactivity in central and peripheral nervous system glial tumors. Hum Pathol 1989;20:772–776.
    External Resources
  10. Wang KL, Wu TT, Resetkova E, Wang H, Correa AM, Hofstetter WL, Swisher SG, Ajani JA, Rashid A, Hamilton SR, Albarracin CT: Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res 2006;12:4598–4604.
    External Resources
  11. Paweletz CP, Ornstein DK, Roth MJ, Bichsel VE, Gillespie JW, Calvert VS, Vocke CD, Hewitt SM, Duray PH, Herring J, Wang QH, Hu N, Linehan WM, Taylor PR, Liotta LA, Emmert-Buck MR, Petricoin EF 3rd: Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma. Cancer Res 2000;60:6293–6297.
    External Resources
  12. Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q, Xie K: Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin a1 expression and nodal metastasis in gastric cancer. Clin Exp Metastasis 2008;25:695–702.
    External Resources
  13. Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, Parente L: Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation. Cancer Biol Ther 2006;5:643–647.
    External Resources
  14. Rodrigo JP, Garcia-Pedrero JM, Fernandez MP, Morgan RO, Suarez C, Herrero A: Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation. Am J Rhinol 2005;19:483–487.
    External Resources
  15. Shen D, Chang HR, Chen Z, He J, Lonsberry V, Elshimali Y, Chia D, Seligson D, Goodglick L, Nelson SF, Gornbein JA: Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses. Biochem Biophys Res Commun 2005;326:218–227.
    External Resources
  16. Shen D, Nooraie F, Elshimali Y, Lonsberry V, He J, Bose S, Chia D, Seligson D, Chang HR, Goodglick L: Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. Hum Pathol 2006;37:1583–1591.
    External Resources
  17. Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS: Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Biochem Biophys Res Commun 2006;345:1022–1032.
    External Resources
  18. Liu JH, Song LB, Zhang X, Guo BH, Feng Y, Li XX, Liao WT, Zeng MS, Huang KH: Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol 2008;97:267–272.
    External Resources
  19. Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, Shields CB, Xu XM: Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. J Neuropathol Exp Neurol 2007;66:932–943.
    External Resources
  20. Perretti M, Solito E: Annexin 1 and neutrophil apoptosis. Biochem Soc Trans 2004;32:507–510.
    External Resources
  21. Parente L, Solito E: Annexin 1: more than an anti-phospholipase protein. Inflamm Res 2004;53:125–132.
    External Resources
  22. Yi M, Schnitzer JE: Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice. Proc Natl Acad Sci USA 2009;106:17886–17891.
    External Resources
  23. Young AL, Prasad KR, Toogood GJ, Lodge JP: Surgical treatment of hilar cholangiocarcinoma in a new era: comparison among leading Eastern and Western centers, Leeds. J Hepatobiliary Pancreat Sci 2010;17:497–504.
    External Resources
  24. Rocha FG, Matsuo K, Blumgart LH, Jarnagin WR: Hilar cholangiocarcinoma: the Memorial Sloan-Kettering Cancer Center experience. J Hepatobiliary Pancreat Sci 2010;17: 490–496.
    External Resources
  25. Yubin L, Chihua F, Zhixiang J, Jinrui O, Zixian L, Jianghua Z, Ye L, Haosheng J, Chaomin L: Surgical management and prognostic factors of hilar cholangiocarcinoma: experience with 115 cases in China. Ann Surg Oncol 2008;15:2113–2119.
    External Resources
  26. Sawada T, Kita J, Rokkaku K, Kato M, Shimoda M, Kubota K: Outcome of surgical resection for hilar cholangiocarcinoma in elderly patients. Hepatogastroenterology 2008;55:1971–1974.
    External Resources
  27. Sano T, Shimada K, Sakamoto Y, Ojima H, Esaki M, Kosuge T: Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilus. Ann Surg Oncol 2008;15:590–599.
    External Resources
  28. Otani K, Chijiiwa K, Kai M, Ohuchida J, Nagano M, Tsuchiya K, Kondo K: Outcome of surgical treatment of hilar cholangiocarcinoma. J Gastrointest Surg 2008;12:1033–1040.
    External Resources
  29. Ramacciato G, Corigliano N, Mercantini P, Di Benedetto F, Masetti M, Ercolani G, Lauro A, De Ruvo N, Pinna AD: Prognostic factors after surgical resection for hilar cholangiocarcinoma (in Italian). Ann Chir 2006;131:379–385.
    External Resources
  30. Ramacciato G, Di Benedetto F, Cautero N, Masetti M, Mercantini P, Corigliano N, Nigri G, Lauro A, Ercolani G, Del Gaudio M, De Ruvo N, Pinna AD: Prognostic factors and long-term outcome after surgery for hilar cholangiocarcinoma. Univariate and multivariate analysis (in Italian). Chir Ital 2004;56:749–759.
    External Resources
  31. Yi B, Zhang BH, Zhang YJ, Jiang XQ, Zhang BH, Yu WL, Chen QB, Wu MC: Surgical procedure and prognosis of hilar cholangiocarcinoma. Hepatobiliary Pancreat Dis Int 2004;3:453–457.
    External Resources
  32. Sasaki M, Yamaguchi J, Ikeda H, Itatsu K, Nakanuma Y: Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies. Hum Pathol 2009;40:1723–1730.
    External Resources
  33. Mosnier JF, Kandel C, Cazals-Hatem D, Bou-Hanna C, Gournay J, Jarry A, Laboisse CL: N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. Mod Pathol 2009;22:182–190.
    External Resources
  34. Thelen A, Scholz A, Benckert C, Schroder M, Weichert W, Wiedenmann B, Neuhaus P, Jonas S: Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma. J Gastroenterol 2008;43:959–966.
    External Resources
  35. Li Y, Zhang Y, Zheng Q: Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci 2005;25:552–554.
    External Resources
  36. Cao Y, Li Y, Edelweiss M, Arun B, Rosen D, Resetkova E, Wu Y, Liu J, Sahin A, Albarracin CT: Loss of annexin A1 expression in breast cancer progression. Appl Immunohistochem Mol Morphol 2008;16:530–534.
    External Resources
  37. Garcia Pedrero JM, Fernandez MP, Morgan RO, Herrero Zapatero A, Gonzalez MV, Suarez Nieto C, Rodrigo JP: Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status. Am J Pathol 2004;164:73–79.
    External Resources
  38. Nomura H, Uzawa K, Yamano Y, Fushimi K, Nakashima D, Kouzu Y, Kasamatsu A, Ogawara K, Shiiba M, Bukawa H, Yokoe H, Tanzawa H: Down-regulation of plasma membranous annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation. J Cancer Res Clin Oncol 2009;135:943–949.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 20, 2010
Accepted: August 16, 2010
Published online: October 06, 2010
Issue release date: December 2010

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2010, Vol.45, No. 3-4

December 2010

Article

Recommend This
TOP