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Original Paper

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Calpain-10 Gene Polymorphism in Type 2 Diabetes Mellitus Patients in the Gaza Strip

Zaharna M.M.a · Abed A.A.b · Sharif F.A.a

Author affiliations

Departments of aMedical Technology and bBiology, Islamic University of Gaza, Gaza City, Palestine

Corresponding Author

Mr. Mazen M. Zaharna

Department of Medical Technology

Islamic University of Gaza

PO Box 108, Gaza City (Palestine)

Tel. +970 59 960 4870, Fax +970 8 286 0800, E-Mail mzaharna@iugaza.edu.ps

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Med Princ Pract 2010;19:457–462

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Abstract

Objective: To examine the role of calpain-10 SNP-44, -43, -63 and del/ins-19 in genetic susceptibility to type 2 diabetes mellitus (T2DM) and associations with triglycerides and total cholesterol in a group of subjects residing in the Gaza Strip. Subjects and Methods: Ninety-six individuals were examined: 48 T2DM patients and 48 controls. The groups were genotyped for calpain-10 SNP-44, -43, -63, and del/ins-19. Mutagenically separated polymerase chain reaction was used to examine SNP-44; del/ins-19 was examined by electrophoresis of the PCR product on agarose gel, while the restriction fragment length polymorphism method was used for SNP-43 and -63. Results: There was evidence that the C allele at SNP-44 played a possible role in susceptibility to T2DM (p = 0.01). T2DM patients with G/A genotype were found to have higher levels of total cholesterol in comparison to those homozygous for allele 1 (G/G) in SNP-43. Total cholesterol levels increased in T2DM patients who are homozygous for del/ins-19 allele 2, in T2DM patients with the 121/221 haplotype combination, and in control subjects with the haplotype combination 111/121. Conclusion: SNP-44 polymorphism of the calpain-10 gene has a significant association with T2DM patients in the Gaza strip. Certain polymorphisms of calpain-10 also have associations with the levels of total cholesterol in both T2DM patients and controls.

© 2010 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 15, 2009
Accepted: August 13, 2009
Published online: September 28, 2010
Issue release date: September 2010

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1011-7571 (Print)
eISSN: 1423-0151 (Online)

For additional information: http://www.karger.com/MPP


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