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Original Report: Patient-Oriented, Translational Research

Right Ventricular Dysfunction in Patients with End-Stage Renal Disease

Paneni F.a · Gregori M.a · Ciavarella G.M.a · Sciarretta S.a · De Biase L.a · Marino L.a · Tocci G.a · Principe F.b · Domenici A.b · Luciani R.b · Punzo G.b · Menè P.b · Volpe M.a, c

Author affiliations

Divisions of aCardiology and bNephrology, 2nd Faculty of Medicine, University of Rome ‘Sapienza’, Sant’Andrea Hospital, Rome, and cIRCCS Neuromed, Polo Molisano, University of Rome ‘Sapienza’, Pozzilli, Italy

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Am J Nephrol 2010;32:432–438

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: August 10, 2010
Accepted: August 27, 2010
Published online: September 30, 2010
Issue release date: November 2010

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

Background: While chronic dialysis treatment has been suggested to increase pulmonary pressure values, right ventricular dysfunction (RVD) is a major cause of death in patients with end-stage renal disease. We investigated the impact of different dialysis treatments on right ventricular function. Methods: We examined 220 subjects grouped as follows: healthy controls (n = 100), peritoneal dialysis (PD; n = 26), hemodialysis (HD) with radial arteriovenous fistula (AVF; n = 62), and HD with brachial AVF (n = 32). Echocardiography including tissue Doppler imaging (TDI) of the right ventricle was performed in all patients. Results: Pulmonary pressure values progressively rose from controls across the 3 dialysis groups (21.7 ± 6.8, 29.7 ± 6.7, 37.9 ± 6.7 and 40.8 ± 6.6 mm Hg, respectively; p < 0.001). TDI indices of right ventricular function were more impaired in HD patients, particularly in those with brachial AVF. RVD, assessed by TDI myocardial performance index, was higher in HD patients compared with PD patients (71.3 vs. 34.6%, p < 0.001). Moreover, the prevalence of RVD further increased in patients with brachial AVF compared with the radial access (90.6 vs. 61.3%, p < 0.001). Conclusions: Compared to DP, HD increases the risk of RVD, particularly in the presence of brachial AVF. TDI may detect early functional failure of the right ventricle in HD patients.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Report: Patient-Oriented, Translational Research

Received: August 10, 2010
Accepted: August 27, 2010
Published online: September 30, 2010
Issue release date: November 2010

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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