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Fine Needle Aspiration

Cytologic Characteristics and β-Catenin Immunocytochemistry on Smear Slide of Cribriform-Morular Variant of Papillary Thyroid Carcinoma

Koo J.S. · Jung W. · Hong S.W.

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Department of Pathology, Yonsei University Health System, Yonsei University College of Medicine, Seoul, South Korea

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Acta Cytologica 2011;55:13–18

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Article / Publication Details

First-Page Preview
Abstract of Fine Needle Aspiration

Received: November 22, 2009
Accepted: December 26, 2009
Published online: November 26, 2010
Issue release date: January – February

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: https://www.karger.com/ACY

Abstract

Objective: The purpose of this study is to analyze the characteristic cytologic features of the cribriform-morular variant of papillary thyroid carcinoma (CVPTC) and to find out the possibility of a preoperative diagnosis of CVPTC in fine needle aspiration (FNA). Study Design: A retrospective review of cytologic features of 5 patients who were diagnosed with CVPTC after thyroidectomy and underwent preoperative FNA was performed. In addition, β-catenin immunocytochemistry on a smear slide was applied. Results: All cases showed a high cellularity smear, cribriform architecture, ovoid/columnar cells, obvious nucleoli, and nuclear groove. Epithelial morules were observed in 4 (80%) cases. All cases demonstrated a nuclear and cytoplasmic expression in β-catenin immunocytochemistry applied to a smear slide. Conclusion: Preoperative diagnosis of CVPTC can be made by cytologic features of cribriform architecture, epithelial morule, and columnar cells in FNA and β-catenin immunocytochemistry on a smear slide showing a nuclear and cytoplasm expression.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Fine Needle Aspiration

Received: November 22, 2009
Accepted: December 26, 2009
Published online: November 26, 2010
Issue release date: January – February

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: https://www.karger.com/ACY


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