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In-Depth Review

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Uric Acid in Hypertension and Renal Disease: The Chicken or the Egg

Kanbay M.a · Solak Y.b · Dogan E.c · Lanaspa M.A.d · Covic A.e

Author affiliations

aDepartment of Medicine, Division of Nephrology, Gulhane School of Medicine, Ankara, bDepartment of Medicine, Division of Nephrology, Selcuk University, Meram School of Medicine, Konya, and cDepartment of Medicine, Division of Nephrology, Sutcu Imam University School of Medicine, Kahramanmaras, Turkey; dDivision of Renal Diseases and Hypertension, University of Colorado-Denver, Denver, Colo., USA; eNephrology Clinic, Dialysis and Renal Transplant Center, ‘C.I. Parhon’ University Hospital, ‘Gr. T. Popa’ University of Medicine and Pharmacy, Iasi, Romania

Corresponding Author

Mehmet Kanbay, MD

Alparslan Mahallesi, Umit sokak

No:25/14, Melikgazi

Kayseri (Turkey)

Tel. +90 505 266 8866, Fax +90 352 223 97 53, E-Mail drkanbay@yahoo.com

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After uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community. Thus, it has been proposed that uric acid might have caused these disorders. However, uric acid suffered a long period of ignorance in which it was considered a metabolically inert substance. However, recent years has witnessed a resurrection of interest. Experimental studies showed an association between increased uric acid and renal arteriolar disease and hypertension. These preliminary results were supported with clinical studies. However, controversy regarding the precise pathophysiologic role of uric acid in inducing hypertension and renal disease remains to be elucidated. Despite being limited at this time, a few randomized intervention studies showed that even treatment of asymptomatic hyperuricemia was beneficial in terms of blood pressure regulation and kidney function. In this review, we focus on the pathophysiologic role of uric acid in the development and progression of renal disease and hypertension. We also discuss recent clinical evidence suggesting a causal role of uric acid in these disease states.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of In-Depth Review

Received: August 04, 2010
Accepted: September 07, 2010
Published online: November 20, 2010
Issue release date: December 2010

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 0

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

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