Medical Principles and Practice
Original Paper
Implication of Umbilical Cord in PreeclampsiaSalama R.H.M.a · Fathalla M.M.F.b · Mekki A.-R.M.a · Elsadek B.E.-K.M.cDepartments of aBiochemistry, and bObstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, and cDepartment of Biochemistry, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
Ragaa H.M. Salama Faculty of Medicine, Assiut University PO Box 71515 Assiut (Egypt) Tel. +20 88 236 9112, Fax +20 88 233 2278, E-Mail ragaa_2002@yahoo.com |
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Abstract
Objectives: To investigate the role of biochemical changes in the umbilical cord and placenta in developing preeclampsia (PE). Subjects and Methods: Thirty women with PE and 15 healthy pregnant women as controls were enrolled in this study. Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 1 (sVEGFR-1), platelet-derived endothelial cell growth factor (PD-ECGF), neutrophil elastase and nitric oxide (NO) were measured. Results: Both serum (maternal and fetal) and tissue (placenta and umbilical cord) levels of VEGF, sVEGFR-1, PD-ECGF and neutrophil elastase were significantly increased, whereas NO was significantly decreased (except placental tissue showed no changes) in preeclamptic patients. The cord serum level of PD-ECGF was significantly higher in severe PE compared to mild PE and normal pregnant women. The placental and cord tissue levels of PD-ECGF and neutrophil elastase were significantly higher in severe PE, while the cord tissue level of NO was significantly lower in severe PE. Conclusion: Our data showed that umbilical cord vessels and stroma can serve as an additional source of vasoactive and angiogenic substances that contribute to the biochemical changes occurring in PE.
© 2011 S. Karger AG, Basel
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Article / Publication Details
Received: July 07, 2009
Accepted: May 30, 2010
Published online: January 20, 2011
Issue release date: January 2011
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 1011-7571 (Print)
eISSN: 1423-0151 (Online)
For additional information: https://www.karger.com/MPP
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