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Published: October 2010

Open Access Gateway

Solitary Peutz-Jeghers Polyp in a Paediatric Patient

Retrosi G.a · Nanni L.a · Vecchio F.M.b · Manzoni C.a · Canali R.a · Busato G.a · Pintus C.a

Author affiliations

aDepartment of Paediatrics, Division of Paediatric Surgery, and bDepartment of Human Pathology, Università Cattolica del Sacro Cuore, Policlinico ‘A. Gemelli’, Rome, Italy

Corresponding Author

Giuseppe Retrosi, MD

Department of Paediatrics, Division of Paediatric SurgeryUniversità Cattolica del Sacro Cuore, Policlinico ‘A. Gemelli’

Largo A. Gemelli 8, IT–00168 Rome (Italy)

Tel. +39 063 015 4032, Fax +39 063 051 162, E-Mail retrosi@alice.it

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Case Rep Gastroenterol 2010;4:452–456

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Hamartomatous polyps of Peutz-Jeghers are mostly found in patients affected by Peutz-Jeghers syndrome (PJS), but they can be rarely encountered in the general population. It is unclear whether a solitary Peutz-Jeghers polyp (PJP) is an incomplete form of PJS or a separate entity. We report a case of solitary PJP in a paediatric patient in whom the other features of PJS were absent. The patient underwent laparotomy due to small bowel intussusception secondary to an ileac polyp. Histological examination showed the characteristic features of PJP, but the patient did not fulfill the WHO criteria for PJS diagnosis (negative family history for PJS and absence of mucocutaneous pigmentation); moreover analysis of the STK11/LKB1 gene did not reveal any genomic abnormality. The clinical and investigative findings in our case suggest that the solitary PJP can be considered a different clinical entity from PJS.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: October 2010

Published online: October 18, 2010
Issue release date: September – December

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

eISSN: 1662-0631 (Online)

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Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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