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Original Research Article

Abdominal Fat, Adipose-Derived Hormones and Mild Cognitive Impairment: The J-SHIPP Study

Kamogawa K.a · Kohara K.a, c · Tabara Y.b, c · Uetani E.a · Nagai T.a · Yamamoto M.a · Igase M.a · Miki T.a, c

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Departments of aGeriatric Medicine and bBasic Medical Research and Education, and cProteo-Medicine Research Center, Ehime University Graduate School of Medicine, Tõon, Japan

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Dement Geriatr Cogn Disord 2010;30:432–439

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: August 10, 2010
Published online: November 17, 2010
Issue release date: December 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background/Aim: Lower body weight in later life has been shown to be associated with dementia. However, abdominal fat distribution under conditions of mild cognitive impairment (MCI) and the possible involvement of leptin and adiponectin in MCI have not been fully investigated. Methods: We analyzed 517 middle-aged-to-elderly community-dwelling persons. Abdominal subcutaneous fat and visceral fat areas were determined using computed tomography, and plasma leptin and adiponectin concentrations were measured in fasting samples. MCI was assessed using the Japanese version of the MCI screening method. Results: In men, the abdominal subcutaneous fat area was significantly lower in participants with MCI than in those with normal cognitive function [median (interquartile range): 107.4 (85.9, 133.1) cm2 vs. 136.4 (93.1, 161.4) cm2; p = 0.002]. Logistic regression analyses with confounding factors including age and abdominal subcutaneous fat area showed that a 10 mg/l increase in plasma adiponectin had a protective effect against the development of MCI in men (odds ratio: 0.46; 95% CI: 0.20–0.97; p = 0.041). In contrast, MCI was not found to be associated with abdominal fat area or adipose-derived hormones in women. Conclusion: Reduced amounts of subcutaneous fat and low levels of plasma adiponectin were found to be associated with MCI in men.

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: August 10, 2010
Published online: November 17, 2010
Issue release date: December 2010

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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