Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Accumulation of Fetal IgG in Immunoglobulin Injection into the Fetal Abdominal Cavity Is Proven

Yoshida M. · Matsuda H. · Hasegawa Y. · Yoshinaga Y. · Asai K. · Kawashima A. · Furuya K.

Author affiliations

Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan

Related Articles for ""

Fetal Diagn Ther 2011;29:229–232

Do you have an account?

Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 06, 2010
Accepted: August 10, 2010
Published online: December 03, 2010
Issue release date: April 2011

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT

Abstract

Objective: There have been a number of studies on immunoglobulin injection into fetuses or mothers during pregnancy for the treatment of congenital cytomegalovirus infection. However, no study has examined the effect of injected immunoglobulin on fetal hemodynamics. In this study, we examined the effect of immunoglobulin injection on fetal hemodynamics by retrospectively measuring the concentrations of several IgG subclasses in stored umbilical cord blood sera collected during fetal therapy. Methods: Five patients who underwent immunoglobulin injection into the fetal abdominal cavity (IFAC) as a fetal therapy during pregnancy were included in this study. Frozen-stored umbilical venous blood samples collected from these patients during IFAC were measured for serum concentrations of each IgG subclass. Results: The largest change was observed in the IgG2 concentration, with a mean increase of 221% following IFAC. The IgG4 concentration also showed a mean increase of 63%. In contrast, the concentration of IgG1, which has the strongest physiological activity of all IgG subclasses examined, only exhibited an overall mean increase of 1.4%. Conclusion: Our results confirmed that immunoglobulins are incorporated into the fetal circulation following IFAC.

© 2010 S. Karger AG, Basel


References

  1. Negishi H, Yamada H, Hirayama E, et al: Intraperitoneal administration of cytomegalovirus hyperimmunoglobulin to the cytomegalovirus-infected fetus. J Perinatol 1998;18:466–469.
  2. Matsuda H, Kawakami Y, Furuya K, et al: Intrauterine therapy for a cytomegalovirus-infected symptomatic fetus. BJOG 2004;111:756–757.
  3. Matsuda H, Sakaguchi K, Shibasaki T, et al: Intrauterine therapy for parvovirus B19-infected symptomatic fetus using B19 IgG-rich high titer gammaglobulin. J Perinat Med 2005;33:561–563.
  4. Nigro G, Adler SP, La Torre R, et al: Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 2005;353:1350–1362.
  5. Adler SP, Nigro G: Findings and conclusions from CMV hyperimmune globulin treatment trials. J Clin Virol 2009;46(suppl 4):S54–S57.
  6. Luppi P: How immune mechanisms are affected by pregnancy. Vaccine 2003;21:3352–3357.
  7. Simister NE: Placental transport of immunoglobulin G. Vaccine 2003;21:3365–3369.
  8. Gitlin D, Boesman M: Serum α-fetoprotein, albumin, and γ-globulin in the human conceptus. J Clin Invest 1966;45:1826–1838.
  9. Gitlin D, Biasucci A: Developent of γG, γA, γM, βIC-βIA, C1 esterase inhibitor, ceruloplasmin, transferrin, hemopexin, heptoglobin, fibrinogen, plasminogen, α1-antitrypsin, orosomucoid, β-lipoprotein, α2-macroglobulin, and prealbumin in the human conceptus. J Clin Invest 1969;48:1433–1446.
  10. Israel EJ, Simister N, Freiberg E, et al: Immunoglobulin G binding sites on the foetal intestine: a possible mechanism for the passive transfer of immunity from mother to infant. Immunology 1993;79:77–81.
  11. Cederqvist LL, Ewool LC, Bonsnes RW, et al: Detectability and pattern of immunoglobulins in normal amniotic fluid throughout gestation. Am J Obstet Gynecol 1978;130:220–224.
  12. Malek A: Ex vivo human placenta models: transport of immunoglobulin G and its subclasses. Vaccine 2003;21:3362–3364.
  13. Garty BZ, Ludomirsky A, Danon YL, et al: Placental transfer of immunoglobulin G subclasses. Clin Diagn Lab Immunol 1994;1:667–669.
  14. Shrim A, Garcia-Bournissen F, Maxwell C, et al: Favorable pregnancy outcome following trastuzumab (Herceptin) use during pregnancy: case report and updated literature review. Reprod Toxicol 2007;23:611–613.
  15. Roopenian DC, Akilesh S: FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007;7:715–725.
  16. Burns JC, Capparelli EV, Brown JA, et al: Intravenous γ-globulin and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group. Pediatr Infect Dis J 1998;17:1144–1148.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 06, 2010
Accepted: August 10, 2010
Published online: December 03, 2010
Issue release date: April 2011

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 3

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.