European Neurology

Original Paper

Integration of Cognitive Impairment in the Expanded Disability Status Scale of 215 Patients with Multiple Sclerosis

Brissart H.a, b · Sauvée M.a · Latarche C.b, c · Dillier C.a · Debouverie M.a–c

Author affiliations

aDepartment of Neurology, Hôpital Central, bNancy-Université, Université Paul Verlaine Metz, Université Paris Descartes, EA 4360 Apemac, and cCentre of Clinical Epidemiology, INSERM CIC-EC, Hôpital Marin, Nancy, France

Keywords: Neuropsychological examinationMultiple sclerosisCognitive dysfunctionEpidemiologyFatigueDepression

Related Articles for ""
Eur Neurol 2010;64:345–350
https://doi.org/10.1159/000322140

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 18, 2010
Accepted: October 18, 2010
Published online: November 13, 2010
Issue release date: December 2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Background: Estimates of the prevalence of cognitive impairment among patients with multiple sclerosis (MS) range between 40 and 70%. The current cerebral functional system (CFS) of the Expanded Disability Status Scale (EDSS) is subjective. Aim: To define a new cerebral functional system (NCFS) based on neuropsychological evaluation (NE). Methods: We prospectively included 215 MS patients. NE evaluated cognitive functions. Fatigue was assessed with the Fatigue Impact Scale. The NCFS was devised with grades from 0 to 5, excluding depression but including fatigue. Grade 1 of the NCFS was integrated in the EDSS as other functional scores. The NCFS and new EDSS including the NCFS were compared with the current CFS and EDSS. Results: 215 patients (69% women, 67% with relapsing-remitting MS, median EDSS 3.0) were assessed. 98% of these patients presented fatigue and/or cognitive impairment with the NCFS compared to 62% with the CFS. The NCFS was higher than the CFS, and the EDSS had changed in 31% of the 113 patients with an EDSS <3.5. Change in functional score was not correlated to current age or age at onset of MS. Conclusions: We propose a new CFS grading based on NE, including fatigue, and integrating grade 1 at EDSS.

© 2010 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 18, 2010
Accepted: October 18, 2010
Published online: November 13, 2010
Issue release date: December 2010

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

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2010, Vol.64, No. 6

December 2010

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Additional Information

H.B. and M.S. contributed equally to this work.
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