IMRT, IGRT, SBRT

Advances in the Treatment Planning and Delivery of Radiotherapy

Editor(s): Meyer, J.L. (San Francisco, CA)

Breast Cancer

Intensity-Modulated Radiotherapy for Breast Cancer: Advances in Whole and Partial Breast Treatment

White J.a · Meyer J.b

Author affiliations

aDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisc., and bDepartment of Radiation Oncology, Saint Francis Memorial Hospital, San Francisco, Calif., USA

Related Articles for ""
Meyer JL (ed): IMRT, IGRT, SBRT – Advances in the Treatment Planning and Delivery of Radiotherapy, ed 2, rev. and ext. Front Radiat Ther Oncol. Basel, Karger, 2011, vol. 43, pp 292–314
https://doi.org/10.1159/000322461

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Complete book

  • Immediate access to all parts of this book
  • Cover-to-cover formats may be available
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restriction for personal use
read more

Pricing depends on hard-cover price

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Breast Cancer

Published online: May 20, 2011
Cover Date: 2011

Number of Print Pages: 23
Number of Figures: 7
Number of Tables: 9

ISBN: 978-3-8055-9680-0 (Print)
eISBN: 978-3-8055-9681-7 (Online)

Abstract

Intensity-modulated radiotherapy (IMRT) can improve dose distributions through the treated breast and also reduce radiation doses to adjacent normal tissues including the contralateral breast, heart and lung with appropriate planning. Analyses demonstrate that the quality of radiation dose distribution does affect clinical results, and that outcomes are enhanced through improved planning and dose delivery methods. To achieve these results, it is essential to carefully define tissue volumes for treatment or avoidance, select technologies that can potentially conform fields to those volumes, use comprehensive planning methods, and assess their results in terms of objective dose constraints. IMRT can also be used to boost the region of tumor excision concurrently with whole breast treatment, an approach now being evaluated in on-going clinical studies. Partial breast irradiation (PBI) has been proposed as an alternative to irradiation of the entire breast for early-stage breast cancer patients undergoing breast conservation treatment. Numerous single institution phase II studies have demonstrated promising results, and the American Society of Radiation Oncology (ASTRO) has defined a suitable group of low-risk patients for PBI treatment off protocol at this time. IMRT has been proposed as an alternative to 3D conformal radiotherapy (3DCRT) for external beam PBI to improve the dose conformality to target volumes and the sparing of normal tissues. There are an increasing number of institutions evaluating and using IMRT instead of 3DCRT for PBI because of the potential treatment advantages for the breast cancer patient.

© 2011 S. Karger AG, Basel



Related Articles:

References

  1. Arriagada R Le MG Rochard F Contesso G: Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group J Clin Oncol 1996; 14: 1558-1564
  2. Blichert-Toft M Rose C Andersen JA: Danish randomized trial comparing breast conservation therapy with mastectomy: six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monogr 1992; 11: 19-25
  3. Fisher B Anderson S Bryant J: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: 1233-1241
  4. Jacobson JA Danforth DN Cowan KH: Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 1995; 332: 907-911
  5. van Dongen JA Voogd AC Fentiman IS: Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000; 92: 1143-1150
  6. Veronesi U Cascinelli N Mariani L: Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347: 1227-1232
  7. Clarke M Collins R Darby S: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 366: 2087-2106
  8. Solin L Fowble B Martz K: Results of the 1983 Patterns of Care process survey for definitive breast irradiation. Int J Radiat Oncol Biol Phys 1991; 20: 105-111
  9. Shank B Moughan J Owen J: The 1993-94 patterns of care process for irradiation after breast conserving surgery - comparison with the 1992 standard for breast conservation treatment. Int J Radiat Oncol Biol Phys 2000; 48: 1291-1299
  10. Pierce LJ Moughan J White J Winchester DP Owen J Wilson JF: 1998-1999 patterns of care study process survey of national practice patterns using breast-conserving surgery and radiotherapy in the management of stage I-II breast cancer. Int J Radiat Oncol Biol Phys 2005; 62: 183-192
  11. Wazer D Dipetrillo T Schmidt-Ullirch R: Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma. J Clin Oncol 1992; 10: 356-363
  12. De La Rochefordiere A Abner A Silver B: Are cosmetic results following conservative surgery and radiation therapy for early breast cancer dependent on technique?. Int J Radiat Oncol Biol Phys 1992; 23: 925-931
  13. Olivotto IA Rose MA Osteen RT: Late cosmetic outcome after conservative sugery and radiotherapy: analysis of causes of cosmetic failure. Int J Radiat Oncol Biol Phys 1989; 17: 747-753
  14. Taylor M Perez C Halverson K: Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 1995; 31: 753-764
  15. Kestin LL Sharpe MD Frazier RC: Intensity modulation to improve dose uniformity with tangential breast radiotherapy: initial clinical experience. Int J Radiat Oncol Biol Phys 2000; 48: 1559-1568
  16. Chui CS Hong L McCormick B: Intensity-modulated radiotherapy technique for three-field breast treatment. Int J Radiat Oncol Biol Phys 2005; 62: 1217-1223
  17. Fong A Bromley R Beat M: Dosimetric comparison of intensity modulated radiotherapy techniques and standard wedged tangents for whole breast radiotherapy. J Med Imaging Radiat Oncol 2009; 53: 92-99
  18. Barnett GC Wilkinson J Moody AM: A randomized controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: Baseline characteristics and dosimetry results. Radiother Oncol 2009; 92: 34-41
  19. Pignol JP Olivotto I Rakovittch et al: A multi-center randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 2008; 26: 2085-2092
  20. Donovan E Bleakley N Denholm E: Randomized trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 2007; 82: 254-264
  21. Freedman GM Tianyu L Nicolaou N: Breast intensity-modulated radiation therapy reduces time spent with acute dermatitis for women of all breast sized during radiation. Int J Radiat Oncol Biol Phys 2009; 74: 689-694
  22. Haroslia A Kestin L Grillis I: Intensity-modulated radiotherapy results in significant decrease in clinical toxicities compared with conventional wedge-based breast radiotherapy. Int J Radiat Oncol Biol Phys 2007; 68: 1375-1380
  23. Vicini FA Sharpe M Kestin L: Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2002; 54: 1336-1344
  24. McDonald MW Godette KD Butker EK: Long-term outcomes of IMRT for breast cancer: a single-institution cohort analysis. Int J Radiat Oncol Biol Phys 2008; 72: 1031-1040
  25. Caudell JJ De Los Santos JF Keene KS: A dosimetric comparison of electronic compensation, conventional intensity modulated radiotherapy, and tomotherapy in patients with early-stage carcinoma of the left breast. Int J Radiat Oncol Biol Phys 2007; 68: 1505-1511
  26. Lohr F El-Haddad M Dobler B: Potential effect of robust and simple IMRT approach for left sided breast cancer on cardiac mortality. Int J Radiat Oncol Biol Phys 2009; 74: 73-80
  27. Bhatnagar AK Brandner E Sonnik D: Intensity modulated radiation therapy (IMRT) reduces the dose to the contralateral breast when compared to conventional tangential fields for primary breast irradiation. Breast Cancer Res Treat 2006; 96: 41-46
  28. Van der Laan HP Dolsma WV Maduro JH: Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy. Radiat Oncol 2008; 3: 6
  29. Wang X Yu TK Salehpur M: Breast cancer regional radiation fields for supraclavicular and axillary lymph node treatment: is the posterior axillary boost field technique optimal?. Int J Radiat Oncol Biol Phys 2009; 74: 86-91
  30. Chadha M Woode R Silanpaa J: Three-week accelerated whole breast radiation therapy with concomitant boost for early stage breast cancer (abstract). Int J Radiat Oncol Biol Phys 2009; 75: ((suppl 1))
  31. Freedman GM Anderson PR Goldstein LJ: Four-week course of radiation for breast cancer using hypofractionated intensity modulated radiation therapy with an incorporated boost. Int J Radiat Oncol Biol Phys 2007; 68: 347-353
  32. Van der Laan HP Dolsma WV Maduro JH: Three dimensional conformal simultaneously integrated boost technique for breast conserving therapy. Int J Radiat Oncol Biol Phys 2007; 68: 1018-1023
  33. Formenti SC Gidea-Addeo D Godlberg JD: Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. J Clin Oncol 2007; 25: 2236-2242
  34. Chen PY Vicini FA Benitez P: Long-term cosmetic results and toxicity after accelerated partial-breast irradiation: a method of radiation delivery by interstitial brachytherapy for the treatment of early-stage breast carcinoma. Cancer 2006; 106: 991-999
  35. King TA Bolton JS Kuske RR: Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg 2000; 180: 299-304
  36. Arthur DW Winter K Kuske RR: A phase II trial of brachytherapy alone after lumpectomy for select breast cancer: tumor control and survival outcomes of RTOG 95-17. Int J Radiation Oncol Biol Phys 2008; 72: 467-473
  37. Vicini F Beitsch PD Quiet CA: Three-year analysis of treatment efficacy, cosmesis, and toxicity by the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial in patients treated with accelerated partial breast irradiation (APBI). Cancer 2008; 112: 758-766
  38. Formenti SC Truong MT Goldberg JD: Prone accelerated partial breast irradiation after breast-conserving surgery: preliminary clinical results and dose-volume histogram analysis. Int J Radiat Oncol Biol Phys 2004; 60: 493-504
  39. Taghian A Kozak K Doppke K: Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys 2006; 64: 1092-1099
  40. Vicini FA Chen P Wallace M: Interim cosmetic results and toxicity suing 3D conformal external beam radiotherapy to deliver accelerated partial breast irradiation in patients with early-stage breast cancer treated with breast conserving therapy. Int J Radiat Oncol Biol Phys 2007; 69: 1124-1130
  41. Vicini FA Winter K Wong J: Initial efficacy of RTOG 0319: three dimensional conformal radiation therapy (3D-CRT) confined to the region of the lumpectomy cavity for stage I/II breast carcinoma. Int J Radiat Oncol Biol Phys 2010; 77: 1120-1127
  42. Bovi J Qi SQ White J: Comparison of three accelerated partial breast irradiation techniques: treatment effectiveness based on biological models. Radiother Oncol 2007; 84: 226-232
  43. Weed DW Edmundson GK Vicini FA: Accelerated partial breast irradiation: a dosimetric comparison of three different techniques. Brachy-therapy 2005; 4: 121-129
  44. Kahn AJ Kirk MC Mehta PS: A dosimetric comparison of three-dimensional conformal intensity - modulated radiation therapy, and MammoSite partial - breast irradiation. Brachytherapy 2006; 5: 183-188
  45. Rusthoven KE Carter DL Howell K: Accelerated partial breast intensity-modulated radiotherapy resulted in improved dose distribution when compared with three dimensional treatment planning techniques. Int J Radiat Oncol Biol Phys 2008; 70: 296-302
  46. Livi L Buonomici FB Simontacchi G: Accelerated partial breast irradiation with IMRT: new technical approach and interim analysis of acute toxicity in a phase III randomized trial. Int J Radiat Oncol Biol Phys 2010; 77: 509-515
  47. Jagsi R Ben-David M Moran J: Unacceptable cosmesis in a protocol investigating intensity modulated radiotherapy with active breathing control for accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 2010; 76: 71-78
  48. Morrow N Stepaniak C White J: Intra and interfractional variation for prone breast irradiation: an indication for image-guided radiotherapy. Int J Radiat Oncol Biol Phys 2007; 69: 910-917
  49. Kainz K White J Herman J: Investigation of helical tomotherapy for partial breast irradiation of prone positioned patients. Int J Radiat Oncol Biol Phys 2009; 74: 275-282

Article / Publication Details

First-Page Preview
Abstract of Breast Cancer

Published online: May 20, 2011
Cover Date: 2011

Number of Print Pages: 23
Number of Figures: 7
Number of Tables: 9

ISBN: 978-3-8055-9680-0 (Print)
eISBN: 978-3-8055-9681-7 (Online)

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

Table of Contents

Article

Recommend This
TOP