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Clinical Study

Outcome of Adjuvant Therapy for Gallbladder Cancer

Park H.S.a · Lim J.Y.a · Yoon D.S.b · Park J.S.b · Lee D.K.a · Lee S.J.a · Choi H.J.c · Song S.Y.c · Lee W.J.d · Cho J.Y.a

Author affiliations

Departments of aInternal Medicine and bSurgery, Gangnam Severance Hospital, and Departments of cInternal Medicine and dSurgery, Shinchon Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Related Articles for ""

Oncology 2010;79:168–173

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: August 30, 2010
Accepted: November 08, 2010
Published online: December 31, 2010
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL

Abstract

Objectives: The aim of this study was to evaluate the outcome of adjuvant therapy on the overall survival (OS) and disease-free survival (DFS) after curative resection (RO) of patients with TNM stage II gallbladder (GB) cancer. Methods: A total of 160 patients who had received curative resection (RO) between January 2000 and December 2009 were retrospectively reviewed. Among 61 stage II GB cancer patients, 43 received adjuvant therapy, while 18 others received surgery alone. The median follow-up period was 27.3 months (range 2.2–98.9 months). Results: OS was not significantly different among the adjuvant therapies (p = 0.180), but DFS was (p = 0.033). The 3-year OS and DFS from surgery alone, adjuvant chemotherapy, adjuvant radiotherapy, and adjuvant concurrent chemo-radiotherapy were 64, 78, 36 and 36%, and 56, 69, 14 and 47%, respectively. Overall, the chemotherapy group had a better prognosis, although there were no significant differences. Conclusions: The data from this study do not provide evidence that adjuvant therapy is an effective treatment option for curative resected GB cancer. A large randomized controlled study is necessary to confirm the efficacy of adjuvant therapy. Newer adjuvant studies should be focused on gemcitabine-based chemotherapy or chemo-radiotherapy with molecular-based target agents.

© 2010 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: August 30, 2010
Accepted: November 08, 2010
Published online: December 31, 2010
Issue release date: March 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: https://www.karger.com/OCL


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