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Environment and Epigenetics

Environmental Hazard in the Aetiology of Somatic and Germ Cell Aneuploidy

Pacchierotti F.a · Eichenlaub-Ritter U.b

Author affiliations

aLaboratory of Toxicology, ENEA CR Casaccia, Rome, Italy; bInstitute of Gene Technology/Microbiology, University of Bielefeld, Bielefeld, Germany

Related Articles for ""

Cytogenet Genome Res 2011;133:254–268

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Article / Publication Details

First-Page Preview
Abstract of Environment and Epigenetics

Published online: January 11, 2011
Issue release date: April 2011

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Sources of environmental exposures to potentially aneugenic agents are many and include occupational and therapeutic exposures, and exposures associated with lifestyle habits. In this present study, some of these agents and exposure scenarios are discussed that involve potentially large population targets and/or seem to affect chromosome segregation by previously unsuspected mechanisms: metals, possibly acting by epigenetic mechanisms; nano-sized particles that might directly interact with subcellular components of the mitotic and meiotic machineries; cytostatic drugs in healthcare occupations; anticancer therapies potentially affecting the genetic integrity of gametes; continuously increasing electromagnetic field exposures with some sparse evidence of aneugenic activity; endocrine disruptors and their seemingly elusive effects in mouse oocytes, including the first evidence that prenatal exposure could affect meiotic nondisjunction in adult life. Hazards are considered for both somatic cells at risk of neoplastic transformation or tumour progression by chromosome loss and gain and germ cells at risk of heritable aneuploidies associated with spontaneous abortions or genetic diseases. Finally, possible synergistic interactions between environmental exposure and ageing or genetic predisposition are considered that could influence ultimate risks.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Environment and Epigenetics

Published online: January 11, 2011
Issue release date: April 2011

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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