Kidney and Blood Pressure Research
Original Paper
Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Complications and Mortality in Patients Undergoing Non-Cardiac Major SurgeryShavit L.a · Dolgoker I.b · Ivgi H.c · Assous M.c · Slotki I.aaAdult Nephrology Unit, bAnesthesiology Department, and cMicrobiology and Immunology Lab, Shaare Zedek Medical Center, Jerusalem, Israel
Linda Shavit, MD Adult Nephrology Unit Shaare Zedek Medical Center, PO Box 3235 Jerusalem 91031 (Israel) E-Mail lshavit@szmc.org.il |
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Abstract
Introduction: We tested the hypothesis that urinary and serum neutrophil gelatinase-associated lipocalins (NGAL) early after non-cardiac major surgery predict postoperative acute kidney injury (AKI), complications and mortality. Methods: We studied 74 patients undergoing orthopedic, vascular and abdominal surgery lasting ≧2 h. NGAL was measured in preoperative, as well as 2- and 6-hour postoperative samples. The primary outcome was AKI. Secondary outcome was postoperative infection and death. Results: 10 patients (13.5%) developed AKI, 19 (26%) reached secondary outcomes, of whom 5 (7%) died. Serum NGAL was significantly higher in patients with diabetes and chronic kidney disease (CKD). No significant correlation was detected between serum or urine NGAL and subsequent development of AKI. Urine NGAL at 6 h and serum NGAL at 2 and 6 h were strongly correlated with postoperative infection and death (p = 0.004, p = 0.013 and p = 0.001, respectively). Conclusions: Our data suggest that in the general surgical population, NGAL could serve as a potent early biomarker for postoperative infection, and that the presence of CKD and diabetes mellitus is associated with higher levels of NGAL and may influence its predictive value.
© 2011 S. Karger AG, Basel
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Article / Publication Details
Received: August 02, 2010
Accepted: December 23, 2010
Published online: February 11, 2011
Issue release date: March 2011
Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 4
ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)
For additional information: https://www.karger.com/KBR
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