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Editor's Choice - Free Access

Modifications of the Innate Immune System in Atopic Dermatitis

Maintz L. · Novak N.

Author affiliations

Department of Dermatology and Allergy, University of Bonn, Bonn, Germany

Corresponding Author

Prof. Dr. Natalija Novak

Department of Dermatology and Allergy

University of Bonn

Sigmund-Freud-Strasse 25, DE–53127 Bonn (Germany)

Tel. +49 228 2871 5370, E-Mail Natalija.Novak@ukb.uni-bonn.de

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J Innate Immun 2011;3:131–141

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Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease which is often complicated by recurrent microbial superinfections. Genetically based modifications which might have an impact on the innate immune system, such as impairment of the skin barrier, modifications of pattern recognition receptors, deficiency of antimicrobial peptides, antiviral natural killer cells and plasmacytoid dendritic cells, facilitate the entry of allergens and infectious microbes into the skin, where they encounter immunocompetent cells. The micromilieu in the skin of AD patients further potentiates dysfunctions of the innate immune system, leading to a vicious circle promoting the disease. This article provides an overview of modifications of the innate immune system in AD.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Received: December 08, 2010
Accepted: January 03, 2011
Published online: January 21, 2011
Issue release date: February 2011

Number of Print Pages: 11
Number of Figures: 1
Number of Tables: 1

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

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