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Original Research

Glutathione S-Transferase Gene Polymorphism as a Susceptibility Factor for Acute Myocardial Infarction and Smoking in the North Indian Population

Singh N.a · Sinha N.a · Kumar S.a · Pandey C.M.b · Agrawal S.c

Author affiliations

Departments of aCardiology, bBiostatistics and Health Informatics, and cMedical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

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Cardiology 2011;118:16–21

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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: October 21, 2010
Accepted: December 28, 2010
Published online: March 10, 2011
Issue release date: April 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Objectives: Glutathione S-transferase (GST) plays a key role in the detoxification of xenobiotic atherogens generated by smoking. We investigated whether functional GST gene polymorphism might be associated with acute myocardial infarction (AMI) and smoking. No such investigation has previously been conducted among North Indians. Methods: 230 patients with AMI and 300 healthy controls of North Indian ethnicity were enrolled in the study. GSTM1/T1/P1 gene polymorphisms were examined using restriction fragment length polymorphism. Results: When GST polymorphism was analyzed in patients with AMI, GSTM1 null genotype frequencies were 0.24 and 0.21 among cases with coronary artery disease and controls, respectively. The respective GSTT1 null genotype frequencies were 0.10 and 0.20 (p = 0.001). GSTP1 variant Val/Val allele frequencies were 0.02 and 0.07 with p = 0.03. After risk factor adjustment, only GSTP1Val/Val was found to be protective against disease. Considering the effect of GST (T1, M1, and P1) gene polymorphism on smoking, subjects were further divided into smokers and nonsmokers. However, GSTT1 null as well as GSTP Val/Val genotypes were protective only in nonsmokers (p = 0.01 and p = 0.04). Conclusions: A significant protective effect of GSTT1 null and GSTP1 Val genotype against disease was observed in patients with AMI although protection was limited to nonsmokers.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: October 21, 2010
Accepted: December 28, 2010
Published online: March 10, 2011
Issue release date: April 2011

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 5

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD


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