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Aneuploidy at Different Life Stages: Embryonic and Prenatal

Mosaic Aneuploidy in Early Fetal Losses

Lebedev I.

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Institute of Medical Genetics, Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia

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Cytogenet Genome Res 2011;133:169–183

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Article / Publication Details

First-Page Preview
Abstract of Aneuploidy at Different Life Stages: Embryonic and Prenatal

Published online: February 09, 2011
Issue release date: April 2011

Number of Print Pages: 15
Number of Figures: 4
Number of Tables: 4

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Chromosomal mosaicism is the presence of 2 or more cell lines with different karyotypes in the same individual. Mosaic karyotypes are a remarkable feature of early stages of human embryo development. They result from mitotic errors in chromosome segregation and demonstrate the clearest example of somatic mutagenesis in human beings. This review is devoted to the classification of chromosomal mosaicism and the analysis of its underlying mechanisms, incidence and phenotypic effects during embryo development. A model for tissue-specific aneuploid cell line compartmentalization in spontaneous abortions is introduced.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Aneuploidy at Different Life Stages: Embryonic and Prenatal

Published online: February 09, 2011
Issue release date: April 2011

Number of Print Pages: 15
Number of Figures: 4
Number of Tables: 4

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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