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Receptor Regulation by Bile Acids

Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

Jansen P.L.M.a · van Werven J.b · Aarts E.c · Berends F.c · Janssen I.c · Stoker J.b · Schaap F.G.a

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Departments of aGastrointestinal and Liver Disease and bRadiology, Academic Medical Center, Amsterdam, and cDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands

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Dig Dis 2011;29:48–51

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Article / Publication Details

First-Page Preview
Abstract of Receptor Regulation by Bile Acids

Published online: June 17, 2011
Issue release date: June 2011

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI

Abstract

Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated.

© 2011 S. Karger AG, Basel


References

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Article / Publication Details

First-Page Preview
Abstract of Receptor Regulation by Bile Acids

Published online: June 17, 2011
Issue release date: June 2011

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: https://www.karger.com/DDI


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