Receptor Regulation by Bile Acids
Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass SurgeryJansen P.L.M.a · van Werven J.b · Aarts E.c · Berends F.c · Janssen I.c · Stoker J.b · Schaap F.G.a
Departments of aGastrointestinal and Liver Disease and bRadiology, Academic Medical Center, Amsterdam, and cDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands
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Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated.
© 2011 S. Karger AG, Basel
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