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Published: February 2011

Open Access Gateway

Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Negative Microscopic Polyangiitis with Pulmonary Haemorrhage and IgA Nephropathy

Endo Y. · Minato H. · Taki R. · Kato M. · Kore-Eda S. · Miyachi Y. · Tanioka M.

Author affiliations

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Corresponding Author

Yuichiro Endo

Department of Dermatology, Graduate School of Medicine, Kyoto University

54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507 (Japan)

Tel. +81 75 751 3310, E-Mail yendou-tky@umin.ac.jp

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Case Rep Dermatol 2011;3:22–27

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Aim: To report a case of a patient with myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-negative microscopic polyangiitis (MPA) and IgA nephropathy associated with severe pulmonary haemorrhage. Case Report: A 59-year-old man presented with ANCA-negative systemic vasculitis accompanied by purpura, nephritis and pulmonary haemorrhage. A skin biopsy specimen revealed pandermal leucocytoclastic vasculitis without IgA deposition and a kidney biopsy showed mesangial nephritis with IgA deposition. Considering these findings, the patient was diagnosed as having MPA with IgA nephropathy. Discussion: In most cases, MPA presents with rapidly progressive necrotizing glomerulonephritis and sometimes lung haemorrhage, while IgA nephropathy is less common among MPA cases. As recent research suggested that in MPA immunoglobulin deposition in the kidney may be an exacerbating factor for renal dysfunction and poor prognosis, close observation is required in these cases.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: February 2011

Published online: February 05, 2011
Issue release date: January – April

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

eISSN: 1662-6567 (Online)

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Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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