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Imaging in Prostate Cancer Diagnosis: Present Role and Future Perspectives

Pinto F. · Totaro A. · Calarco A. · Sacco E. · Volpe A. · Racioppi M. · D’Addessi A. · Gulino G. · Bassi P.F.

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Department of Urology, Catholic University of Sacred Heart, Rome, Italy

Corresponding Author

Francesco Pinto

Department of Urology, Catholic University of Sacred Heart

Largo A. Gemelli

IT–00168 Rome (Italy)

Tel. +39 06 3015 5290, E-Mail francesco.pinto@libero.it

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Urol Int 2011;86:373–382

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Prostate cancer (PCa) remains a major health concern for the male population. Detection and primary diagnosis of PCa are based on digital rectal examination, serum prostate-specific antigen levels, and transrectal ultrasound (TRUS)-guided random biopsy. Moreover, the gold standard for detecting PCa, systematic biopsy, lacks sensitivity as well as grading accuracy. This review summarizes recent developments of ultrasonography modalities and functional magnetic resonance imaging (MRI) in the diagnosis of PCa. A comparison between the different methods is presented, including their clinical value and usefulness. It is concluded that innovative ultrasound techniques (including ultrasound contrast agents, 3-D and 4-D sonography, elastography and harmonic sonography) promise benefits in comparison to standard TRUS to accurately diagnose PCa. Promising advances have been made in the detection of PCa with multiparametric MRI. The combination of conventional and functional MRI techniques (including diffusion-weighted imaging, dynamic contrast-enhanced MRI, and MR spectroscopy) can provide information for differentiating PCa from noncancerous tissue and can be used for MRI-guided biopsies, especially in patients with persistent elevation of serum prostate-specific antigen and previous negative TRUS-guided biopsies. However, functional MRI technique and MRI-guided biopsy remain expensive and complex tools presenting inherent challenges.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Published online: March 02, 2011
Issue release date: June 2011

Number of Print Pages: 10
Number of Figures: 6
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

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