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Meta-Analysis of Homogeneous Subgroups Reveals Association between PDE4D Gene Variants and Ischemic Stroke

Yoon D.a · Park S.K.c–e · Kang D.c–e · Park T.b · Park J.W.f

Author affiliations

aInterdisciplinary Program in Bioinformatics, and bDepartment of Statistics, College of Natural Science, Seoul National University, cDepartment of Preventive Medicine, Seoul National University College of Medicine, dCancer Research Institute, Seoul National University, and eDepartment of Biomedical Science, Seoul National University Graduate School, Seoul, and fDepartment of Medical Genetics, Hallym University College of Medicine, Chuncheon, Republic of Korea

Corresponding Author

Dr. Ji Wan Park

Department of Medical Genetics

Hallym University College of Medicine, 39 Hallymdaehak-gil

Chuncheon, Gangwon-do 200-702 (Republic of Korea)

Tel. +82 33 248 2691, E-Mail jwpark@hallym.ac.kr

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Neuroepidemiology 2011;36:213–222

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Background: An Icelandic study showed a significant positive association between phosphodiesterase 4D (PDE4D) gene variants and stroke. However, subsequent studies reported conflicting results, possibly due to small sample sizes and the heterogeneity of the studies. Method: We performed a meta-analysis on 6 SNPs of the PDE4D gene to investigate the association between this gene and ischemic stroke by integrating the results of previous studies, comprising 11,834 cases and 15,233 controls. A pooled genotypic odds ratio (OR) for each SNP was determined under 3 genetic models (i.e. dominant, recessive, and codominant) using both fixed- and random-effects models with consideration for heterogeneity and publication bias across studies. Results: Among the SNPs included in this study, SNP56 (rs702553) showed the most significant association with ischemic stroke in a meta-analysis comprised of 7 homogenous studies. The overall OR of the TT genotype compared to the AA genotype was 1.29 (95% CI 1.03–1.61; p = 0.022). For SNP83 (rs966221), a protective effect of the ancestral allele T was observed only in Asian populations (ORTT 0.79, 95% CI 0.69–0.90; p = 0.0005). This meta-analysis revealed a significant association of PDE4D gene variants with the risk of ischemic stroke, and further investigations are warranted to evaluate possible ethnic-specific effects.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Received: December 01, 2010
Accepted: March 30, 2011
Published online: June 16, 2011
Issue release date: July 2011

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

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