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Immunosenescence of Human Natural Killer Cells

Gayoso I.a · Sanchez-Correa B.b · Campos C.a · Alonso C.a · Pera A.a · Casado J.G.b · Morgado S.b · Tarazona R.b · Solana R.a

Author affiliations

aDepartment of Immunology, IMIBIC – Reina Sofia University Hospital, University of Cordoba, Cordoba, and bImmunology Unit, Department of Physiology, University of Extremadura, Cáceres, Spain

Corresponding Author

Dr. Rafael Solana

Department of Immunology, Faculty of Medicine

Reina Sofia University Hospital, University of Cordoba

ES–14004 Cordoba (Spain)

Tel. +34 957 011 493, E-Mail rsolana@uco.es

Related Articles for ""

J Innate Immun 2011;3:337–343

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Natural killer (NK) cells are a key component of innate immunity involved not only in the elimination of virus-infected or tumor cells but also in the regulation of the immune response by producing cytokines and chemokines that can activate other cellular components of innate and adaptive immunity. NK cell subsets are differentially affected by aging. Whereas CD56bright cells are decreased in healthy elderly individuals, the CD56dim subset is expanded. The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly; this supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56bright NK cells and an increase in highly differentiated CD56dim CD57+ NK cells. This NK cell redistribution can explain many of the phenotypic and functional changes in NK cells associated with healthy aging such as decreased proliferation and the maintenance of CD16-dependent cytotoxicity.

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: November 01, 2010
Accepted: March 31, 2011
Published online: May 11, 2011
Issue release date: June 2011

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 1

ISSN: 1662-811X (Print)
eISSN: 1662-8128 (Online)

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