Neurosignals

Original Paper

Free Access

Subthalamic Local Field Beta Oscillations during Ongoing Deep Brain Stimulation in Parkinson’s Disease in Hyperacute and Chronic Phases

Rosa M.a · Giannicola G.a · Servello D.b · Marceglia S.a · Pacchetti C.c · Porta M.b · Sassi M.b · Scelzo E.a · Barbieri S.d · Priori A.a, e

Author affiliations

aCentro Clinico per la Neurostimolazione, le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, e bNeurochirurgia Funzionale e Clinica Tourette, IRCCS Galeazzi, Milano, cUnità Operativa Parkinson e Disordini del Movimento, IRCCS Istituto Neurologico Mondino, Pavia, dUnità Operativa di Neurofisiopatologia Clinica, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, e eDipartimento di Scienze Neurologiche, Università degli Studi di Milano, Milano, Italia

Corresponding Author

Alberto Priori, MD, PhD, Dipartimento di Scienze Neurologiche

Università degli Studi di Milano, Centro Clinico per la Neurostimolazione,

le Neurotecnologie ed i Disordini del Movimento, Fondazione IRCCS Ca’ Granda

Ospedale Maggiore Policlinico, Via F. Sforza 35, IT–20122 Milano (Italy)

Tel. +39 02 5503 3621, E-Mail alberto.priori@unimi.it

Keywords: Subthalamic nucleusLocal field potentialDeep brain stimulationChronic recordingHyperacute recordingParkinsonߣs diseaseBeta activityAdaptive deep brain stimulation system

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Neurosignals 2011;19:151–162
https://doi.org/10.1159/000328508

Abstract

In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2–7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p = 0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p = 0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system.

© 2011 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 22, 2010
Accepted: April 04, 2011
Published online: July 12, 2011
Issue release date: August 2011

Number of Print Pages: 12
Number of Figures: 4
Number of Tables: 3

ISSN: 1424-862X (Print)
eISSN: 1424-8638 (Online)

For additional information: https://www.karger.com/NSG

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