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Research Article

Sensitivity to Lovastatin of Saccharomyces cerevisiae Strains Deleted for Pleiotropic Drug Resistance (PDR) Genes

Formenti L.R. · Kielland-Brandt M.C.

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Department of Systems Biology, Center for Microbial Biotechnology, Technical University of Denmark, Lyngby, Denmark

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J Mol Microbiol Biotechnol 2011;20:191–195

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Published online: July 12, 2011
Issue release date: October 2011

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: https://www.karger.com/MMB

Abstract

The use of statins is well established in human therapy, and model organisms such as Saccharomyces cerevisiae are commonly used in studies of drug action at molecular and cellular levels. The investigation of the resistance mechanisms towards statins may suggest new approaches to improve therapy based on the use of statins. We investigated the susceptibility to lovastatin of S. cerevisiae strains deleted for PDR genes, responsible for exporting hydrophobic and amphiphilic drugs, such as lovastatin. Strains deleted for the genes tested, PDR1, PDR3, PDR5 and SNQ2, exhibited remarkably different phenotypes, with deletion of PDR5 causing the highest sensitivity to lovastatin. The study helped clarifying which pdr mutants to use in studies of physiological actions of statins in yeast.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Research Article

Published online: July 12, 2011
Issue release date: October 2011

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1464-1801 (Print)
eISSN: 1660-2412 (Online)

For additional information: https://www.karger.com/MMB


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