Growing Bacteria Shed Elicitors of Drosophila Humoral ImmunityKarlsson J. · Oldenvi S. · Fahlander C. · Daenthanasanmak A. · Steiner H.
Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
Dr. Håkan Steiner
Department of Genetics, Microbiology and Toxicology
SE–106 91 Stockholm (Sweden)
Tel. +46 8 164 161, E-Mail email@example.com
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It has been much debated how the Drosophila immune system can recognize bacterial peptidoglycan that is often hidden. We show that bacteria separated from Drosophila S2 cells by a semipermeable membrane can upregulate the Imd pathway. Supernatants from exponentially growing but not from stationary-phase bacterial cultures induce antimicrobial peptides. It is also made likely that the shed elicitors are of peptidoglycan nature.
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