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Original Paper

Expression of Arachidonate Metabolism Enzymes and Receptors in Nasal Polyps of Aspirin-Hypersensitive Asthmatics

Adamusiak A.M.a · Stasikowska-Kanicka O.c · Lewandowska-Polak A.b · Danilewicz M.c · Wagrowska-Danilewicz M.c · Jankowski A.d · Kowalski M.L.b · Pawliczak R.a

Author affiliations

Departments of aAllergology, Immunology and Dermatology, bClinical Immunology and Microbiology, cPathomorphology and dOtolaryngology, Medical University of Lodz, Lodz, Poland

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Int Arch Allergy Immunol 2012;157:354–362

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 31, 2010
Accepted: May 27, 2011
Published online: November 24, 2011
Issue release date: March 2012

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: The pathogenesis of rhinosinusitis in aspirin-exacerbated airway disease is closely linked to the disequilibrium in arachidonic acid metabolism. Although considerable amounts of data concerning impaired eicosanoid production are available, the precise mechanism and pathogenesis of the disease are still unknown. The aim of the present study was to assess the expression of enzymes belonging to the arachidonic acid cascade and receptors for arachidonate derivative metabolites in nasal polyps from aspirin- hypersensitive (AH) and aspirin-tolerant (AT) patients with rhinosinusitis. Methods: Cells expressing cysteinyl leukotriene (CysLT) receptors (CysLT1 and CysLT2), arachidonate 5-lipoxygenase, leukotriene B4 receptor type 1, E-prostanoid receptors (EP2 and EP4), cyclooxygenase (COX)-1 and COX-2 were detected by immunocytochemistry in nasal polyps obtained from 10 AH patients and 18 AT patients. Results: There was a significantly higher density of cells expressing CysLT1 and CysLT2 receptors in nasal polyps from AH patients than from AT patients (p < 0.001). In contrast, the density of cells expressing EP2 receptor and COX-2 was significantly lower in AH patients than in AT patients (p < 0.02). The number of COX-2-positive epithelial cells was significantly reduced in AH polyps (p < 0.04). Conclusions: The elevated number of nasal polyp cells expressing CysLT receptors and lack of cells expressing EP2 receptor and COX-2 may be related to a more severe course of hyperplastic rhinosinusitis in aspirin hypersensitivity.

© 2011 S. Karger AG, Basel


References

  1. Kowalski M, Makowska JS: Aspirin-exacerbated respiratory disease. An update on diagnosis and management. Allergy Clin Immunol Int: J World Allergy Org 2006;18:150–153.
    External Resources
  2. Stevenson DD, Szczeklik A: Clinical and pathologic perspectives on aspirin sensitivity and asthma. J Allergy Clin Immunol 2006;118:773–786, quiz 787–788.
  3. Stevenson DD, Sanchez-Borges M, Szczeklik A: Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes. Ann Allergy Asthma Immunol 2001;87:177–180.
  4. Berges-Gimeno MP, Simon RA, Stevenson DD: The natural history and clinical characteristics of aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol 2002;89:474–478.
  5. Hosemann W: Surgical treatment of nasal polyposis in patients with aspirin intolerance. Thorax 2000;55(suppl 2):S87–S90.
  6. Jantti-Alanko S, Holopainen E, Malmberg H: Recurrence of nasal polyps after surgical treatment. Rhinol Suppl 1989;8:59–64.
  7. Kowalski M, Bienkiewicz B, Pawliczak R, Kordek P: Nasal polyposis in aspirin-hypersensitive patients with asthma (aspirin triad) and aspirin-tolerant patients. Allergy Clin Immunol Int: J World Allergy Org 2003;15:246–250.
    External Resources
  8. Perez-Novo CA, Watelet JB, Claeys C, Van Cauwenberge P, Bachert C: Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 2005;115:1189–1196.
  9. Szczeklik A, Sanak M: The broken balance in aspirin hypersensitivity. Eur J Pharmacol 2006;533:145–155.
  10. Kowalski ML, Pawliczak R, Wozniak J, Siuda K, Poniatowska M, Iwaszkiewicz J, Kornatowski T, Kaliner MA: Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med 2000;161:391–398.
  11. Picado C, Fernandez-Morata JC, Juan M, Roca-Ferrer J, Fuentes M, Xaubet A, Mullol J: Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am J Respir Crit Care Med 1999;160:291–296.
  12. Narumiya S, Sugimoto Y, Ushikubi F: Prostanoid receptors: structures, properties, and functions. Physiol Rev 1999;79:1193–1226.
  13. Ying S, Meng Q, Scadding G, Parikh A, Corrigan CJ, Lee TH: Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells. J Allergy Clin Immunol 2006;117:312–318.
  14. Ferreri NR, Howland WC, Stevenson DD, Spiegelberg HL: Release of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin. Am Rev Respir Dis 1988;137:847–854.
  15. Higashi N, Taniguchi M, Mita H, Osame M, Akiyama K: A comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma. Clin Exp Allergy 2002;32:1484–1490.
  16. Kowalski ML, Sliwinska-Kowalska M, Igarashi Y, White MV, Wojciechowska B, Brayton P, Kaulbach H, Rozniecki J, Kaliner MA: Nasal secretions in response to acetylsalicylic acid. J Allergy Clin Immunol 1993;91:580–598.
  17. Picado C, Ramis I, Rosello J, Prat J, Bulbena O, Plaza V, Montserrat JM, Gelpi E: Release of peptide leukotriene into nasal secretions after local instillation of aspirin in aspirin-sensitive asthmatic patients. Am Rev Respir Dis 1992;145:65–69.
  18. Togias AG, Naclerio RM, Peters SP, Nimmagadda I, Proud D, Kagey-Sobotka A, Adkinson NF Jr, Norman PS, Lichtenstein LM: Local generation of sulfidopeptide leukotrienes upon nasal provocation with cold, dry air. Am Rev Respir Dis 1986;133:1133–1137.
  19. Corrigan C, Mallett K, Ying S, Roberts D, Parikh A, Scadding G, Lee T: Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis. J Allergy Clin Immunol 2005;115:316–322.
  20. Sousa AR, Parikh A, Scadding G, Corrigan CJ, Lee TH: Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. N Engl J Med 2002;347:1493–1499.
  21. Dahlen B, Nizankowska E, Szczeklik A, Zetterstrom O, Bochenek G, Kumlin M, Mastalerz L, Pinis G, Swanson LJ, Boodhoo TI, Wright S, Dube LM, Dahlen SE: Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin-intolerant asthmatics. Am J Respir Crit Care Med 1998;157:1187–1194.
  22. Dahlen SE, Malmstrom K, Nizankowska E, Dahlen B, Kuna P, Kowalski M, Lumry WR, Picado C, Stevenson DD, Bousquet J, Pauwels R, Holgate ST, Shahane A, Zhang J, Reiss TF, Szczeklik A: Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2002;165:9–14.
  23. Kowalski ML, Ptasinska A, Jedrzejczak M, Bienkiewicz B, Cieslak M, Grzegorczyk J, Pawliczak R, Dubuske L: Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest). Allergy 2005;60:1139–1145.
  24. Jinnai N, Sakagami T, Sekigawa T, Kakihara M, Nakajima T, Yoshida K, Goto S, Hasegawa T, Koshino T, Hasegawa Y, Inoue H, Suzuki N, Sano Y, Inoue I: Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet 2004;13:3203–3217.
  25. Park JS, Chang HS, Park CS, Lee JH, Lee YM, Choi JH, Park HS, Kim LH, Park BL, Choi YH, Shin HD: Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet Genomics 2005;15:483–492.
  26. Sanak M, Simon HU, Szczeklik A: Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet 1997;350:1599–1600.
  27. Park TJ, Kim JH, Bae JS, Park BL, Cheong HS, Chun JY, Lee JS, Kim JY, Pasaje CF, Cho SH, Uh ST, Kim MK, Choi IS, Koh IS, Park CS, Shin HD: Possible association of SLC22A2 polymorphisms with aspirin-intolerant asthma. Int Arch Allergy Immunol 2011;155:395–402.
  28. Fokkens W, Lund V, Bachert C, Clement P, Helllings P, Holmstrom M, Jones N, Kalogjera L, Kennedy D, Kowalski M, Malmberg H, Mullol J, Passali D, Stammberger H, Stierna P: EAACI position paper on rhinosinusitis and nasal polyps executive summary. Allergy 2005;60:583–601.
  29. Global Initiative for Asthma (GINA): Global Strategy for Asthma Management and Prevention. NIH Publication No 02-3659. 2006. www.ginasthma.org.
  30. Nizankowska E, Bestynska-Krypel A, Cmiel A, Szczeklik A: Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma. Eur Respir J 2000;15:863–869.
  31. Guilemany JM, Roca-Ferrer J, Mullol J: Cyclooxygenases and the pathogenesis of chronic rhinosinusitis and nasal polyposis. Curr Allergy Asthma Rep 2008;8:219–226.
  32. Peters-Golden M: Expanding roles for leukotrienes in airway inflammation. Curr Allergy Asthma Rep 2008;8:367–373.
  33. Cowburn AS, Sladek K, Soja J, Adamek L, Nizankowska E, Szczeklik A, Lam BK, Penrose JF, Austen FK, Holgate ST, Sampson AP: Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 1998;101:834–846.
  34. Kowalski ML, Grzegorczyk J, Pawliczak R, Kornatowski T, Wagrowska-Danilewicz M, Danilewicz M: Decreased apoptosis and distinct profile of infiltrating cells in the nasal polyps of patients with aspirin hypersensitivity. Allergy 2002;57:493–500.
  35. Varga EM, Jacobson MR, Masuyama K, Rak S, Till SJ, Darby Y, Hamid Q, Lund V, Scadding GK, Durham SR: Inflammatory cell populations and cytokine mRNA expression in the nasal mucosa in aspirin-sensitive rhinitis. Eur Respir J 1999;14:610–615.
  36. Sousa AR, Lams BE, Pfister R, Christie PE, Schmitz M, Lee TH: Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in aspirin-sensitive and non-aspirin-sensitive asthmatic airways. Am J Respir Crit Care Med 1997;156:1384–1389.
  37. Pods R, Ross D, van Hulst S, Rudack C, Maune S: RANTES, eotaxin and eotaxin-2 expression and production in patients with aspirin triad. Allergy 2003;58:1165–1170.
  38. Kowalski ML, Lewandowska-Polak A, Wozniak J, Ptasinska A, Jankowski A, Wagrowska-Danilewicz M, Danilewicz M, Pawliczak R: Association of stem cell factor expression in nasal polyp epithelial cells with aspirin sensitivity and asthma. Allergy 2005;60:631–637.
  39. Thivierge M, Doty M, Johnson J, Stankova J, Rola-Pleszczynski M: IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. J Immunol 2000;165:5221–5226.
  40. Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JA: Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: functional distinction from CysLT1R. Proc Natl Acad Sci USA 2003;100:11589–11593.
  41. Kim SH, Yang EM, Park HJ, Ye YM, Lee HY, Park HS: Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. J Clin Immunol 2007;27:613–619.
  42. Kim SH, Oh JM, Kim YS, Palmer LJ, Suh CH, Nahm DH, Park HS: Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. Clin Exp Allergy 2006;36:433–439.
  43. Roca-Ferrer J, Garcia-Garcia FJ, Pereda J, Perez-Gonzalez M, Pujols L, Alobid I, Mullol J, Picado C: Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. J Allergy Clin Immunol 2011;128:66–72.e1.
  44. Mastalerz L, Sanak M, Gawlewicz-Mroczka A, Gielicz A, Cmiel A, Szczeklik A: Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity. Thorax 2008;63:27–34.
  45. Pierzchalska M, Szabo Z, Sanak M, Soja J, Szczeklik A: Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. J Allergy Clin Immunol 2003;111:1041–1048.
  46. Picado C, Bioque G, Roca-Ferrer J, Pujols L, Mullol J, Benitez P, Bulbena O: Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy 2003;58:122–126.
  47. Pujols L, Mullol J, Alobid I, Roca-Ferrer J, Xaubet A, Picado C: Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma. J Allergy Clin Immunol 2004;114:814–819.
  48. Schafer D, Schmid M, Gode UC, Baenkler HW: Dynamics of eicosanoids in peripheral blood cells during bronchial provocation in aspirin-intolerant asthmatics. Eur Respir J 1999;13:638–646.
  49. Van Sambeek R, Stevenson DD, Baldasaro M, Lam BK, Zhao J, Yoshida S, Yandora C, Drazen JM, Penrose JF: 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol 2000;106:72–76.
  50. Szczeklik A: Aspirin-induced asthma as a viral disease. Clin Allergy 1988;18:15–20.
  51. Schafer D, Lindenthal U, Wagner M, Bolcskei PL, Baenkler HW: Effect of prostaglandin E2 on eicosanoid release by human bronchial biopsy specimens from normal and inflamed mucosa. Thorax 1996;51:919–923.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 31, 2010
Accepted: May 27, 2011
Published online: November 24, 2011
Issue release date: March 2012

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 4

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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