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Fetal Surgery for Myelomeningocele: Patient Selection, Perioperative Management and Outcomes

Danzer E. · Adzick N.S.

Author affiliations

The Center for Fetal Diagnosis and Treatment, The Children’s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Penn., USA

Corresponding Author

N. Scott Adzick, MD

The Center for Fetal Diagnosis and Treatment, 5th Floor Wood Center

The Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard

Philadelphia, PA 19104-4388 (USA)

Tel. +1 215 590 2727, E-Mail adzick@email.chop.edu

Related Articles for ""

Fetal Diagn Ther 2011;30:163–173

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Myelomeningocele (MMC), one of the most common congenital malformations, can result in severe lifelong disabilities, including paraplegia, hydrocephalus, Chiari II malformation (CM-II), incontinence, sexual dysfunction, skeletal deformations and mental impairment. MMC was the first nonlethal anomaly to be treated by fetal surgery. Experimental and clinical evidence suggests that the primary cause of the neurologic deficit associated with MMC is not simply incomplete neurulation but rather chronic mechanical injury and amniotic fluid-induced chemical trauma that progressively damages the exposed neural tissue during gestation. Case series and a prospective, randomized study show that fetal surgery for MMC before 26 weeks’ gestation may preserve neurologic function, reverse the hindbrain herniation of the CM-II and obviate the need for postnatal placement of a ventriculoperitoneal shunt. However, these studies also demonstrate that fetal surgery is associated with significant maternal and fetal risks. Consequently, further research is warranted to further expand our understanding of the pathophysiology of MMC, to evaluate the long-term impact of in utero intervention and to refine the timing and technique of fetal MMC surgery.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Review

Received: May 22, 2011
Accepted: May 31, 2011
Published online: August 18, 2011
Issue release date: November 2011

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

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