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Original Paper

Hemotrophic Mycoplasmas Induce Programmed Cell Death in Red Blood Cells

Felder K.M.1 · Hoelzle K.1 · Ritzmann M.2 · Kilchling T.3 · Schiele D.3 · Heinritzi K.3 · Groebel K.1 · Hoelzle L.E.1,4

Author affiliations

1Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Zurich,2Clinic for Swine, University of Veterinary Medicine, Vienna,3Clinic for Swine, Ludwig-Maximilians-University Munich, Munich,4Institute of Environmental and Animal Hygiene and Veterinary Medicine (with Animal Clinic), University Hohenheim, Stuttgart

Corresponding Author

Prof. Dr. L. E. Hoelzle

Institute of Environmental and Animal Hygiene

and Veterinary Medicine (with Animal Clinic),

Garbenstrasse 30, D-70599 Stuttgart (Germany)

Tel. +49 711 459-22427, Fax +49 711 459-22431

Related Articles for ""

Cell Physiol Biochem 2011;27:557–564

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Abstract

Hemotrophic mycoplasmas (HM) are uncultivable bacteria found on and in the red blood cells (RBCs). The main clinical sign of HM infections is the hemolytic anemia. However, anemia-inducing pathogenesis has not been totally clarified. In this work we used the splenectomized pig as animal model and Mycoplasma suis as a representative for hemotrophic mycoplasmas to study anemia pathogenesis. Eryptosis, i.e. programmed cell death of RBCs, is characterized by cell shrinkage, microvesiculation and phosphatidylserine (PS) exposure on the outer membrane. The eryptosis occurrence and its influence on anemia pathogenesis was observed over the time-course of M. suis infections in pigs using 3 M. suis isolates of differing virulence. All 3 isolates induced eryptosis, but with different characteristics. The occurrence of eryptosis could as well be confirmed in vitro: serum and plasma of an acutely ill pig induced PS exposure on erythrocytes drawn from healthy pigs. Since M. suis is able to induce eryptotic processes it is concluded that eryptosis is one anemia-inducing factor during M. suis infections and, therefore, plays a significant role in the pathogenesis of infectious anemia due to HM infection.

© 2011 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: May 09, 2011
Published online: June 15, 2011
Issue release date: June 2011

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: https://www.karger.com/CPB


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