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Published: August 2011

Open Access Gateway

A Case of Angioleiomyoma with Epithelioid Granuloma

Onishi M. · Takahashi K. · Watabe D. · Onodera H. · Akasaka T.

Author affiliations

Department of Dermatology, Iwate Medical University, Morioka, Japan

Corresponding Author

Masazumi Onishi

Department of DermatologyIwate Medical University

19-1 Uchimaru, Morioka 020-8505 (Japan)

E-Mail monishi@iwate-med.ac.jp

Related Articles for ""

Case Rep Dermatol 2011;3:170–174

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We describe a 61-year-old Japanese woman who had been aware of a lesion on her left thigh for 10 years. Pathological examination demonstrated a well-circumscribed encapsulated nodule at the dermal-subcutaneous boundary, composed of eosinophilic spindle cell bundles, connective tissue, and numerous small vessels. Immunohistochemically, these eosinophilic cells were positive for α-smooth muscle actin. The granulomatous areas in the tumor were composed focally of epithelioid cells and lymphocytes. The epithelioid cells were negative for α-smooth muscle actin. We diagnosed this case as an angioleiomyoma with epithelioid granuloma. Malignant tumors with granulomatous change have sometimes been reported in the literature, but benign tumors with epithelioid granuloma, such as the present one, are rare. We thought that epithelioid cell granuloma might transform to angioleiomyoma through the action of IL-1 released from vascular smooth muscle cells.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: August 2011

Published online: August 25, 2011
Issue release date: May – August

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 1

eISSN: 1662-6567 (Online)

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Open Access License / Drug Dosage / Disclaimer

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