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Parkin: Much More than a Simple Ubiquitin Ligase

Alves da Costa C. · Checler F.

Author affiliations

Institut de Pharmacologie Moléculaire et Cellulaire et Institut de NeuroMédecine Moléculaire, Equipe Labellisée Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, France

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Neurodegenerative Dis 2012;10:49–51

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 16, 2011
Accepted: September 04, 2011
Published online: December 23, 2011
Issue release date: April 2012

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

Abstract

Parkin is mainly a cytosolic protein involved in a subset of Parkinson’s disease (PD) cases referred to as autosomal juvenile recessive forms of PD. Most studies have established as a dogma that parkin function could be resumed as an ubiquitin ligase activity. Accordingly, several cellular functions ascribed to parkin derive from its ability to ubiquitinate a series of proteins, thereby rendering them prone to proteasomal degradation. Several lines of data indicated that parkin could display antiapoptotic properties and we demonstrated that indeed, parkin could downregulate the p53-dependent pathway. However, we showed that such function remained independent of parkin’s ability to act as an ubiquitin ligase. Thus, we established that parkin repressed p53 transcription by physically interacting with its promoter. Here, we describe this novel parkin-associated transcription factor function and we speculate on putative additional transcriptional targets.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: June 16, 2011
Accepted: September 04, 2011
Published online: December 23, 2011
Issue release date: April 2012

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD


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