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Original Paper

Leaky Gut in Patients with Diarrhea-Predominant Irritable Bowel Syndrome and Inactive Ulcerative Colitis

Gecse K.a · Róka R.a · Séra T.b · Rosztóczy A.a · Annaházi A.a · Izbéki F.a · Nagy F.a · Molnár T.a · Szepes Z.a · Pávics L.b · Bueno L.c · Wittmann T.a

Author affiliations

aFirst Department of Internal Medicine and bDepartment of Nuclear Medicine, University of Szeged, Szeged, Hungary; cINRA, UMR 1054 INRA-EI Purpan, Neuro-Gastroenterology and Nutrition Unit, Toulouse, France

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Digestion 2012;85:40–46

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 13, 2011
Accepted: September 13, 2011
Published online: December 14, 2011
Issue release date: January 2012

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Background/Aims: Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. Methods: IBS patients of the diarrhea-predominant (IBS-D) and of the constipation-predominant subgroup (IBS-C), patients with inactive UC and healthy subjects were enrolled. Gut permeability was evaluated by measuring 24-hour urine excretion of orally administered 51Cr-EDTA. Clinical symptoms were evaluated in IBS-D patients and correlated to colonic permeability. Results: There was a significant decrease in the proximal small intestinal permeability in IBS-C patients compared to controls (0.26 ± 0.05 vs. 0.63 ± 0.1%; p < 0.05). Distal small intestinal permeability showed no significant difference in the studied group of patients compared to controls. Colonic permeability of IBS-D and inactive UC patients was significantly increased compared to controls (2.68 ± 0.35 and 3.74 ± 0.49 vs. 1.04 ± 0.18%; p < 0.05, p < 0.001). Colonic permeability of IBS-D patients correlated with stool frequency. Conclusions: Elevated gut permeability is localized to the colon both in IBS-D and in inactive UC patients.

© 2011 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 13, 2011
Accepted: September 13, 2011
Published online: December 14, 2011
Issue release date: January 2012

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 1

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG


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