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Original Paper

Prospective Randomized Study on the Efficacy of Blue Light in the Treatment of Psoriasis Vulgaris

Weinstabl A. · Hoff-Lesch S. · Merk H.F. · von Felbert V.

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Department of Dermatology and Allergology, University Hospital, RWTH Aachen University, Aachen, Germany

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Dermatology 2011;223:251–259

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 26, 2011
Accepted: September 20, 2011
Published online: November 18, 2011
Issue release date: December 2011

Number of Print Pages: 9
Number of Figures: 8
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background:Blue light has no known toxic effects on human skin, but reduces the proliferative capacity of keratinocytes in vitro. We therefore investigated the efficacy of blue light in the treatment of psoriasis vulgaris (PV). Methods: Forty patients with mild to moderate PV and bilateral plaques were assigned to two groups. Group 1 (n = 20) received irradiation at home with blue light (light-emitting diode, LED, emission maximum: 420 nm) once daily for 4 weeks. In parallel, group 2 (n = 20) performed irradiations with another blue light device (LED emission maximum: 453 nm). The contralateral control plaques remained untreated in both groups. Results: Thirty-seven patients completed the trial. The main study parameter, the difference of Local Psoriasis Severity Index (LPSI) scores of the irradiated plaques compared to the control plaques, showed statistically significant improvement after 4 weeks of treatment in both groups [group 1 (420 nm): n = 17, p = 0.04; group 2 (453 nm): n = 20, p = 0.04]. Accordingly, plaque status as assessed by both the physicians and the patients improved continuously during the 4 weeks of treatment and steadily declined thereafter. Conclusion: Blue light appears to be a promising treatment modality in PV that warrants further evaluation in larger studies.

© 2011 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 26, 2011
Accepted: September 20, 2011
Published online: November 18, 2011
Issue release date: December 2011

Number of Print Pages: 9
Number of Figures: 8
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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