European Surgical Research

Original Paper

Prognostic Factors for Survival post Surgery for Patients with Gastrointestinal Stromal Tumors

Mrowiec S.a · Jabłońska B.a · Liszka Ł.b · Pająk J.b · Leidgens M.c · Szydło R.d · Sandecka A.e · Lampe P.a

Author affiliations

aDepartment of Digestive Tract Surgery, University Hospital of the Medical University of Silesia, and bDepartment of Histopathology, Medical University of Silesia, Katowice, and cDivision of General Surgery, City Hospital, Siemianowice Ślą;skie, Poland; dDepartment of Haematology, Hammermsith Hospital, Imperial College, London, and eWithybush Hospital, Haverfordwest, UK

Keywords: Gastrointestinal stromal tumorPrognostic factorMitotic indexSurvival rate

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Eur Surg Res 2012;48:3–9
https://doi.org/10.1159/000334172

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 15, 2010
Accepted: August 15, 2011
Published online: December 14, 2011
Issue release date: March 2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 5

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms located in the alimentary tract. Our aim was to assess the influence of prognostic factors on survival in patients surgically treated for GISTs. Study: One hundred and five patients treated between January 1989 and December 2008 were available for study. A retrospective analysis of prognostic factors (age, gender, mitotic index, tumor location, tumor size, risk of malignant behavior, and coexisting other neoplasm) was performed. Univariate and multivariate survival analyses were undertaken. Results: Univariate analyses revealed the importance of patient gender (p = 0.007), disease location (p = 0.055), mitotic index (p = 0.054) and coexistence with other neoplasms (p = 0.004). However, multivariate analysis showed 3 independently statistically significant factors: coexistence with other neoplasm (RR = 3.53, p = 0.004), male gender (RR = 2.60, p = 0.011) and mitotic index ≧10/50 HPF, (RR = 2.60, p = 0.042). Conclusions: Our study has shown that male gender, a high mitotic index ≧10/50 HPF, and coexistence with other malignant neoplasms were independent poor prognostic factors in patients with GIST. The presence of middle or lower gut disease location leads to an increased risk of mortality when compared with the upper gut.

© 2011 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 15, 2010
Accepted: August 15, 2011
Published online: December 14, 2011
Issue release date: March 2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 5

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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