Original Article · Originalarbeit
Feasibility of Involved-Field Conformal Radiotherapy for Cervical and Upper-Thoracic Esophageal CancerMa J.-B.a,b · Song Y.-P.a,b · Yu J.-M.a,c · Zhou W.a,c · Cheng E.-C.b · Zhang X.-Q.c · Kong L.c
aDepartment of Oncology, Shandong University, School of Medicine, bDepartment of Radiation Oncology, Yantai Yuhuangding Hospital, School of Medicine, Qingdao University, Yantai, cDepartment of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan, Shandong, P.R. China
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Background: The aim of this study was to investigate the feasibility of involved-field irradiation (IFI) for the treatment of cervical and upper-thoracic esophageal cancer with concurrent chemoradiation. Patients and Methods: 102 eligible patients with cervical or upper-thoracic esophageal cancer were treated with concurrent chemoradiation and randomized to either an IFI or elective nodal irradiation (ENI) group. Results: Adverse events included infection (27.4 vs. 64.7%) and nausea (25.4 vs. 54.9%), with a statistically significant difference between the IFI and the ENI group (p = 0.008 and 0.028, respectively). No difference was seen for late radiation reaction. The cumulative incidence of local/regional failure (13.7 vs. 17.6%) and regional lymph failure (7.8 vs. 9.8%) showed no statistically significant difference between the IFI versus the ENI group (p = 0.837 and 0.837, respectively). A nodal out-field relapse rate of only 2% was seen in the IFI group. 3-year survival rates for the ENI and IFI group were 41.3 and 32.0%, respectively (p = 0.58), and 3-year local control rates were 85.7 and 80.1%, respectively (p = 0.34). Conclusion: IFI was acceptable for cervical and upper-thoracic esophageal cancer with a decrease in acute toxicities and no increase in lymph node failure.
© 2011 S. Karger AG, Basel
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