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Published: November 2011

Open Access Gateway

Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging

Iimuro Y.a · Asano Y.a · Suzumura K.a · Yada A.a · Hirano T.a · Iijima H.b · Nishiguchi S.b · Hirota S.c · Fujimoto J.a

Author affiliations

Departments of aSurgery, bMedicine and cSurgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan

Corresponding Author

Yuji Iimuro, MD, PhD

Department of Surgery, Hyogo College of Medicine

1-1 Mukogawa-cho, Nishinomiya 663-8501 (Japan)

Tel. +81 798 456 582, E-Mail siimuro@hyo-med.ac.jp

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Case Rep Gastroenterol 2011;5:628–635

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Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US) demonstrated unique enhancement in the late vascular phase, which was incompatible with those observed in hepatocellular carcinoma, cholangiocellular carcinoma, or metastatic adenocarcinoma. The patient underwent surgical resection of the tumor followed by systemic chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP), while radiation chemotherapy was not applied because of relatively poor performance status. Although postoperative image analysis revealed no recurrence 4 months later, the patient died 13 months after the operation from recurrence. Immunohistological analysis of the resected specimen revealed that this SCC contained many capillary endothelial vessels expressing CD31 or CD34, possibly reflecting the unique imaging pattern in the late vascular phase of CE-US, which has been reported in choangiolocellular carcinoma. In addition, we reviewed which kind of treatment would be suitable for advanced hepatic primary SCC in the literature. From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver.

© 2011 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Published: November 2011

Published online: November 05, 2011
Issue release date: September – December

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

eISSN: 1662-0631 (Online)

For additional information: https://www.karger.com/CRG

Open Access License / Drug Dosage / Disclaimer

Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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