Neonatology
Research Briefings
The ‘Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)’ Study: Background, Aims, and Study ProtocolaDepartment of Neonatology, University Children’s Hospital, Vienna, Austria; Departments of bNeonatology, and cAnaesthesia and Pain Management, The Royal Children’s Hospital, Parkville, Vic., dMurdoch Children’s Research Institute, and eClinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, and fDepartment of Paediatrics, The University of Melbourne, Melbourne, Vic., Australia
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Neonatology 2012;101:301–305
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Article / Publication Details
First-Page Preview
Received: September 27, 2011
Accepted: November 10, 2011
Published online: January 27, 2012
Issue release date: June 2012
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
Abstract
Background: Infants with extremely low birth weight uniformly develop anemia of prematurity and frequently require red blood cell transfusions (RBCTs). Although RBCT is widely practiced, the indications remain controversial in the absence of conclusive data on the long-term effects of RBCT. Objectives: To summarize the current equipoise and to outline the study protocol of the ‘Effects of Transfusion Thresholds on Neurocognitive Outcome of extremely low birth-weight infants (ETTNO)’ study. Methods: Review of the literature and design of a large pragmatic randomized controlled trial of restrictive versus liberal RBCT guidelines enrolling 920 infants with birth weights of 400–999 g with long-term neurodevelopmental follow-up. Results and Conclusions: The results of ETTNO will provide definite data about the efficacy and safety of restrictive versus liberal RBCT guidelines in very preterm infants.
© 2012 S. Karger AG, Basel
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Article / Publication Details
First-Page Preview
Received: September 27, 2011
Accepted: November 10, 2011
Published online: January 27, 2012
Issue release date: June 2012
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1
ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)
For additional information: https://www.karger.com/NEO
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