Case Reports in Oncology
Published: December 2012
Primary Yolk Sac Tumor of the Omentum: A Case Report and Literature ReviewHarano K.a · Ando M.c · Sasajima Y.b · Yunokawa M.a · Yonemori K.a · Shimizu C.a · Tamura K.a · Katsumata N.a · Tsuda H.b · Fujiwara Y.aaBreast and Medical Oncology Division and bPathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, and cDepartment of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
Masashi Ando Department of Clinical Oncology Aichi Cancer Center Hospital, 1-1 Kanokoden Chikusa-ku, Nagoya 464-8681 (Japan) Tel. +81 3 3542 2511, E-Mail mandoh@aichi-cc.jp |
|
Abstract
Yolk sac tumor (YST) is a rare malignant tumor originating from germ cells. YST normally originates from the gonads, rarely occurring in extragonadal sites. We report a 35-year-old man with YST arising in the omentum, which is the first reported case of a primary YST of the omentum in an adult male. The patient presented to the community hospital with abdominal distension. A CT scan showed thickening of the omentum with ascites. The patient underwent open biopsy of the omental mass. The Pathology Department of the hospital could not make a definitive diagnosis at that time, and the tumor was considered a cancer of unknown primary (CUP) origin with features of primary colorectal cancer based on the immunohistochemistry (IHC) findings of the biopsy specimen (CK7–/CK20+ and CDX-2+). He was then referred to our hospital. We found that serum α-fetoprotein was abnormally elevated to 7,144 ng/ml (normal <10.0), and reevaluation of the biopsy specimen revealed microcystic or reticular patterns of tumor cells with Schiller-Duval bodies typical of YST. The present case suggests that IHC is a very useful diagnostic tool for subtyping CUP but should be interpreted in the context of clinical and morphological findings.
© 2012 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Published online: December 20, 2012
Issue release date: September – December
Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0
eISSN: 1662-6575 (Online)
For additional information: https://www.karger.com/CRO
Open Access License / Drug Dosage / Disclaimer
Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
