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Review

Innovation in Surfactant Therapy II: Surfactant Administration by Aerosolization

Pillow J.a, b, d · Minocchieri S.c, d

Author affiliations

aCentre for Neonatal Research and Education, bSchool of Women’s and Infants’ Health, and cSchool of Paediatrics and Child Health, University of Western Australia, and dNeonatal Unit, Princess Margaret and King Edward Memorial Hospitals, Perth, W.A., Australia

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Neonatology 2012;101:337–344

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: June 01, 2012
Issue release date: June 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Instilled bolus surfactant is the only approved surfactant treatment for neonatal respiratory distress syndrome. However, recent trends towards increased utilization of noninvasive respiratory support for preterm infants with surfactant deficiency have created a demand for a similarly noninvasive means of administering exogenous surfactant. Past approaches to surfactant nebulization met with varying success due to inefficient aerosol devices resulting in low intrapulmonary delivery doses of surfactant with variable clinical effectiveness. The recent development of vibrating membrane nebulizers, coupled with appropriate positioning of the interface device, indicates that efficient delivery of aerosolized surfactant is now a realistic goal in infants. Evidence of clinical effect despite low total administered dose in pilot studies, together with suggestions of enhanced homogeneity of pulmonary distribution indicate that this therapy may be applied in a cost-effective manner, with minimal patient handling and disruption. These studies need to be subjected to appropriately designed randomized controlled trials. Further work is also required to determine the optimum delivery route (mask, intranasal prong, nasopharyngeal or laryngeal), dosing amount and redosing interval.

© 2012 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: June 01, 2012
Issue release date: June 2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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