Dermatology

Original Paper

Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Teraki Y. · Hitomi K. · Sato Y. · Izaki S.

Author affiliations

Department of Dermatology, Saitama Medical University, Saitama Medical Center, Saitama, Japan

Keywords: Topical steroidsDemodex mitesTacrolimus ointmentRosacea-like dermatitisPerioral dermatitisTopical calcineurin inhibitors

Related Articles for ""
Dermatology 2012;224:309–314
https://doi.org/10.1159/000338693

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 13, 2011
Accepted: April 10, 2012
Published online: May 22, 2012
Issue release date: August 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Recently, reports have indicated that the continuous use of topical calcineurin inhibitors such as tacrolimus may induce rosacea-like dermatitis (RD). Objective and Methods: To assess clinical features of RD associated with tacrolimus, 44 cases of patients diagnosed with RD between 2005 and 2010 at our hospital were retrospectively reviewed. Results: In total, 22 cases were caused by topical steroid use, 8 by topical tacrolimus use, and 8 by consecutive treatment with topical steroids and tacrolimus. Clinical presentation was basically similar among the 3 groups, although the nose was less frequently affected and pustules were rarely observed in the latter 2 sets of cases. Demodex mites were often found in smears of skin lesions from patients with RD caused by steroids and tacrolimus. Treatment with topical metronidazole was effective in most RD patients. Conclusion: Topical tacrolimus is becoming an important cause of RD along with topical steroids.

© 2012 S. Karger AG, Basel



Related Articles:

References

  1. Chen AY, Zirwas MJ: Steroid-induced rosacealike dermatitis: case report and review of the literature. Cutis 2009;83:198–204.
    External Resources
  2. Hafeez ZH: Perioral dermatitis: an update. Int J Dermatol 2003;42:514–517.
    External Resources
  3. Lipozencic J, Ljubojevic S: Perioral dermatitis. Clin Dermatol 2011;29:157–161.
    External Resources
  4. Lübbe J, Stucky L, Saurat JH: Rosaceiform dermatitis with follicular Demodex after treatment of facial atopic dermatitis with 1% pimecrolimus cream. Dermatology 2003;207:204–205.
    External Resources
  5. Bernard LA, Cunningham BB, Al-Suwaidan S, Friedlander SF, Eichenfield LF: A rosacea-like granulomatous eruption in a patient using tacrolimus ointment for atopic dermatitis. Arch Dermatol 2003;139:229–231.
    External Resources
  6. Antille C, Saurat JH, Lübbe J: Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment. Arch Dermatol 2004;140:457–460.
    External Resources
  7. El Sayed F, Ammoury A, Dhaybi R, Bazex J: Rosaceiform eruption to pimecrolimus. J Am Acad Dermatol 2006;54:548–550.
    External Resources
  8. Fujiwara S, Okubo Y, Irisawa R, Tsuboi R: Rosaceiform dermatitis associated with topical tacrolimus treatment. J Am Acad Dermatol 2010;62:1050–1052.
    External Resources
  9. Forton F, Seys B: Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br J Dermatol 1993;128:650–659.
    External Resources
  10. Bonnar E, Eustace P, Powell FC: The Demodex mite population in rosacea. J Am Acad Dermatol 1993;28:443–448.
    External Resources
  11. Beck LA: The efficacy and safety of tacrolimus ointment: a clinical review. J Am Acad Dermatol 2005;53(suppl 2):S165–S170.
    External Resources
  12. Carroll CL, Fleischer AB Jr: Tacrolimus ointment: the treatment of atopic dermatitis and other inflammatory cutaneous disease. Expert Opin Pharmacother 2004;5:2127–2137.
    External Resources
  13. Lacey N, Ní Raghallaigh S, Powell FC: Demodex mites – commensals, parasites or mutualistic organisms? Dermatology 2011;222:128–130.
    External Resources
  14. Goldman D: Tacrolimus ointment for the treatment of steroid-induced rosacea: a preliminary report. J Am Acad Dermatol 2001;44:995–998.
    External Resources
  15. Chu CY: An open-label pilot study to evaluate the safety and efficacy of topically applied pimecrolimus cream for the treatment of steroid-induced rosacea-like eruption. J Eur Acad Dermatol Venereol 2007;21:484–490.
    External Resources
  16. Schwarz T, Kreiselmaier I, Bieber T, et al: A randomized, double-blind, vehicle-controlled study of 1% pimecrolimus cream in adult patients with perioral dermatitis. J Am Acad Dermatol 2008;59:34–40.
    External Resources
  17. McClellan KJ, Noble S: Topical metronidazole: a review of its use in rosacea. Am J Clin Dermatol 2000;1:191–199.
    External Resources
  18. Zip C: An update on the role of topical metronidazole in rosacea. Skin Therapy Lett 2006;11:1–4.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 13, 2011
Accepted: April 10, 2012
Published online: May 22, 2012
Issue release date: August 2012

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2012, Vol.224, No. 4

August 2012

Article

Recommend This
TOP