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Schizophrenia and Substance Abuse Comorbidity: Nicotine Addiction and the Neonatal Quinpirole Model

Brown R.W.a · Maple A.M.a · Perna M.K.a · Sheppard A.B.a · Cope Z.A.a · Kostrzewa R.M.b

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aDepartment of Psychology, East Tennessee State University, and bDepartment of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, Tenn., USA

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Dev Neurosci 2012;34:140–151

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: October 12, 2011
Accepted: April 12, 2012
Published online: July 06, 2012
Issue release date: September 2012

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

Abstract

This review focuses on nicotine comorbidity in schizophrenia, and the insight into this problem provided by rodent models of schizophrenia. A particular focus is on age differences in the response to nicotine, and how this relates to the development of the disease and difficulties in treatment. Schizophrenia is a particularly difficult disease to model in rodents due to the fact that it has a plethora of symptoms ranging from paranoia and delusions of grandeur to anhedonia and negative affect. The basis of these symptoms is believed to be due to neurochemical abnormalities and neuropathology in the brain, which most models have attempted to emulate. A brief review of findings regarding nicotine use and abuse in schizophrenics is presented, with findings using rodent models that have been able to provide insight into the mechanisms of addiction. A common clinical approach to the treatment of nicotine addiction in the schizophrenic population has been that these drugs are used for self-medication purposes, and it is clear that self-medication may actually be directed at several symptoms, including cognitive impairment and anhedonia. Finally, our laboratory has reported across a series of studies that neonatal treatment with the dopamine D2/D3 receptor agonist quinpirole results in long-term increases in dopamine-like receptor sensitivity, consistent with data reporting increases in dopamine D2 receptor function in schizophrenia. Across these studies, we have reported several behavioral, neurochemical, and genetic consistencies with the disease, and present a hypothesis for what we believe to be the basis of psychostimulant addiction in schizophrenia.

© 2012 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: October 12, 2011
Accepted: April 12, 2012
Published online: July 06, 2012
Issue release date: September 2012

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE


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