Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Tamsulosin for Ureteral Stones: A Systematic Review and Meta-Analysis of a Randomized Controlled Trial

Lu Z.a · Dong Z.a · Ding H.a · Wang H.b · Ma B.a · Wang Z.a

Author affiliations

aInstitute of Urology, Key Laboratory of Diseases of Urological System Gansu Province, Gansu Nephro-Urological Clinical Center, The Second Hospital of Lanzhou University, Lanzhou, and bSchool of Medicine, Shandong University, Shandong, China

Related Articles for ""

Urol Int 2012;89:107–115

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 19, 2011
Accepted: April 14, 2012
Published online: June 22, 2012
Issue release date: July 2012

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN

Abstract

Background/Aims: To evaluate the efficacy of tamsulosin as a medical expulsive therapy of ureteral stones. Methods: We searched PubMed, EMBASE, the Cochrane Library, and ISI-Science Citation Index up to December 2011. All randomized controlled trials were identified in which patients were randomized to receive either tamsulosin or standard therapy with/without placebo for ureteral stones. Outcome measures assessed were overall stone expulsion rate (primary) and expulsion time, and the number of pain episodes (secondary). Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.0. Results: Twenty-nine trials with a total of 2,763 patients met the inclusion criteria. The pooled analysis showed a 19% improvement in stone clearance with tamsulosin. According to the doses of tamsulosin, the pooling effects of tamsulosin were analyzed, with a higher expulsion rate obtained than in controls. Compared with calcium channel blockers, there was a higher stone expulsion rate in tamsulosin. In addition, a shorter expulsion time, fewer colic episodes and adverse effects were observed. Conclusions: Tamsulosin is a safe and effective medical expulsive therapy choice for ureteral stones. It should be recommended for most patients with distal ureteral stones before stones are 10 mm in size. In future, high-quality multicenter, randomized and placebo-controlled trials are needed to evaluate the outcome.

© 2012 S. Karger AG, Basel


References

  1. Stefanos PJ, Michael C: Trussa: Treatment strategies of ureteral stones. EAU-EBU Update Series 2006;4:184–190.
    External Resources
  2. Menon M, Parulkar BC, Drash GW, et al: Urinary lithiasis: etiology, diagnosis, diagnosis and medical management; in Walsh PC (ed): Campbell’s Urology. Philadelphia, Saunders, 1998, pp 2661–2733.
  3. Bihl G, Meyers A: Recurrent renal stone disease-advances in pathogenesis and clinical management. Lancet 2001;358:651–656.
  4. Pearle MS, Calhoun EA, Curhan GC: Urologic diseases in America project: urolithiasis. J Urol 2005;173:848–857.
    External Resources
  5. Preminger GM, Tiselius HG, Assimos DG, Alken P, Buck C, Gallucci M, Knoll T, Lingeman JE, Nakada SY, Pearle MS, Sarica K, Turk C, Wolf JS: 2007 guideline for the management of ureteral calculi. J Urol 2007;178:2418–2434.
  6. De Sio M, Autorino R, Di Lorenzo G, Damiano R, Giordano D, Cosentino L, Pane U, Di Giacomo F, Mordente S, D’Armiento M: Medical expulsive treatment of distal-ureteral stones using tamsulosin: a single-center experience. J Endourol 2006;20:12–16.
  7. Pedro RN, Hinck B, Hendlin K, Feia K, Canales BK, Monga M: Alfuzosin stone expulsion therapy for distal ureteral calculi: a double-blind, placebo-controlled study. J Urol 2008;179:2244–2247.
    External Resources
  8. Zehri AA, Ather MH, Abbas F, Biyabani SR: Preliminary study of efficacy of doxazosin as a medical expulsive therapy of distal ureteric stones in a randomized clinical trial. Urology 2010;75:1285–1288.
    External Resources
  9. Wang CJ, Huang SW, Chang CH: Efficacy of an α1-blocker in expulsive therapy of lower ureteral stones. J Endourol 2008;22:41–46.
    External Resources
  10. Hermanns T, Sauermann P, Rufibach K, Frauenfelder T, Sulser T, Strebel RT: Is there a role for tamsulosin in the treatment of distal ureteral stones of 7 mm or less? Results of a randomised, double-blind, placebo-controlled trial. Eur Urol 2009;56:407–412.
    External Resources
  11. Vincendeau S, Bellissant E, Houlgatte A, Dore B, Bruyere F, Renault A, Mouchel C, Bensalah K, Guille F: Tamsulosin hydrochloride vs. placebo for management of distal ureteral stones: a multicentric, randomized, double-blind trial. Arch Intern Med 2010;170:2021–2027.
  12. Ferre RM, Wasielewski JN, Strout TD, Perron AD: Tamsulosin for ureteral stones in the emergency department: a randomized, controlled trial. Ann Emerg Med 2009;54:432–439, e431–432.
    External Resources
  13. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ: Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996;17:1–12.
  14. Higgins JP, Green S (eds): Cochrane Handbook for Systematic Reviews of Interventions, Version 5.0.2, updated September 2009. The Cochrane Collaboration 2009.
  15. Abdel-Meguid TA, Tayib A, Al-Sayyad A: Tamsulosin to treat uncomplicated distal ureteral calculi: a double-blind randomized placebo-controlled trial. Can J Urol 2010;17:5178–5183.
    External Resources
  16. Agrawal M, Gupta M, Gupta A, Agrawal A, Sarkari A, Lavania P: Prospective randomized trial comparing efficacy of alfuzosin and tamsulosin in management of lower ureteral stones. Urology 2009;73:706–709.
    External Resources
  17. Al-Ansari A, Al-Naimi A, Alobaidy A, Assadiq K, Azmi MD, Shokeir AA: Efficacy of tamsulosin in the management of lower ureteral stones: a randomized double-blind placebo-controlled study of 100 patients. Urology 2010;75:4–7.
    External Resources
  18. Ahmed AF, Al-Sayed AY.: Tamsulosin versus alfuzosin in the treatment of patients with distal ureteral stones: prospective, randomized, comparative study. Korean J Urol 2010;51:193–197.
    External Resources
  19. Autorino R, De Sio M, Damiano R, Di Lorenzo G, Perdona S, Russo A, Quarto G, Cosentino L, D’Armiento M: The use of tamsulosin in the medical treatment of ureteral calculi: where do we stand? Urol Res 2005;33:460–464.
  20. Cervenakov I, Fillo J, Mardiak J, Kopecny M, Smirala J, Lepies P: Speedy elimination of ureterolithiasis in lower part of ureters with the α1-blocker – tamsulosin. Int Urol Nephrol 2002;34:25–29.
  21. Dellabella M, Milanese G, Muzzonigro G: Efficacy of tamsulosin in the medical management of juxtavesical ureteral stones. J Urol 2003;170:2202–2205.
  22. Dellabella M, Milanese G, Muzzonigro G: Randomized trial of the efficacy of tamsulosin, nifedipine and phloroglucinol in medical expulsive therapy for distal ureteral calculi. J Urol 2005;174:167–172.
  23. Erturhan S, Erbagci A, Yagci F, Celik M, Solakhan M, Sarica K: Comparative evaluation of efficacy of use of tamsulosin and/or tolterodine for medical treatment of distal ureteral stones. Urology 2007;69:633–636.
  24. Han MC, Park YY, Shim BS: Effect of tamsulosin on the expectant treatment of lower ureteral stones. Korean J Urol 2006;47:708–711.
    External Resources
  25. Kaneko T, Matsushima H, Morimoto H, Tsuzaka Y, Homma Y: Efficacy of low-dose tamsulosin in medical expulsive therapy for ureteral stones in Japanese male patients: a randomized controlled study. Int J Urol 2010;17:462–465.
  26. Kang DI, Cho WY, Kim TH, Chung JM, Park J, Yoon JH, Lee SD: Effect of tamsulosin 0.2 mg on the short-term treatment of urinary stones: multicenter, prospective, randomized study. Korean J Urol 2009;50:586–590.
    External Resources
  27. Keshvary M, Taghavi R: The effect of tamsulosin and nifedipine in facilitating juxtavesical stones’ passage. Med J Mashhad University Med Sci 2006;48:425–430.
  28. Kim JS, Shim BS, Han MC: Effect of tamsulosin in the expectant therapy of lower ureteral stones. Int J Urol 2006;13(suppl):A25.
  29. Küpeli B, Irkilata L, Gurocak S, Tunc L, Kirac M, Karaoglan U, Bozkirli I: Does tamsulosin enhance lower ureteral stone clearance with or without shock wave lithotripsy? Urology 2004;64:1111–1115.
  30. Lojanapiwat B, Kochakarn W, Suparatchatpan N, Lertwuttichaikul K: Effectiveness of low-dose and standard-dose tamsulosin in the treatment of distal ureteric stones: a randomized controlled study. J Int Med Res 2008;36:529–536.
  31. Lv J, Wei L, Zhang H, Ding S: Comparison of tamsulosin versus nifedipine for the management of lower ureteral stones. Chin J Urol 2006;27:612–614.
  32. Porpiglia F, Ghignone G, Fiori C, Fontana D, Scarpa RM: Nifedipine versus tamsulosin for the management of lower ureteral stones. J Urol 2004;172:568–571.
  33. Resim S, Ekerbicer H, Ciftci A: Effect of tamsulosin on the number and intensity of ureteral colic in patients with lower ureteral calculus. Int J Urol 2005;12:615–620.
  34. Sayed MA, Abolyosr A, Abdalla MA, El-Azab AS: Efficacy of tamsulosin in medical expulsive therapy for distal ureteral calculi. Scand J Urol Nephrol 2008;42:59–62.
  35. Taghavi R, Darabi MR, Tavakoli K: Survey of the effect of tamsulosin and nifedipine on facilitating juxtavesical ureteral stone passage. J Endourol 2005;19(suppl 1):A9.
    External Resources
  36. Yencilek F, Erturhan S, Canguven O, Koyuncu H, Erol B, Sarica K: Does tamsulosin change the management of proximally located ureteral stones? Urol Res 2010;38:195–199.
    External Resources
  37. Yilmaz E, Batislam E, Basar MM, Tuglu D, Ferhat M, Basar H: The comparison and efficacy of three different α1-adrenergic blockers for distal ureteral stones. J Urol 2005;173:2010–2012.
  38. Zhang MY, Ding ST, Lu JJ, Lue YH, Zhang H, Xia QH: Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones. Chin Med J (Engl) 2009;122:798–801.
  39. Parsons JK, Hergan LA, Sakamoto K, Lakin C: Efficacy of α-blockers for the treatment of ureteral stones. J Urol 2007;177:983–987.
  40. Seitz C, Liatsikos E, Porpiglia F, Tiselius HG, Zwergel U: Medical therapy to facilitate the passage of stones: what is the evidence? Eur Urol 2009;56:455–471.
    External Resources
  41. Sivula A, Lehtonen T: Spontaneous passage of artificial concretions applied in the rabbit ureter. Scand J Urol Nephrol 1967;1:259–263.
  42. Egger M, Davey Smith G, Schneider M: Systematic reviews of observational studies; in Egger M, Davey Smith G, Altman DG (eds): Systematic Reviews in Healthcare – Meta-Analysis in Context. London, BMJ Publishing, 2001, pp 211–227.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 19, 2011
Accepted: April 14, 2012
Published online: June 22, 2012
Issue release date: July 2012

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: https://www.karger.com/UIN


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.