Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Risk Assessment of Hymenoptera Re-Sting Frequency: Implications for Decision-Making in Venom Immunotherapy

von Moos S.a · Graf N.a · Johansen P.b · Müllner G.c · Kündig T.M.b · Senti G.a

Author affiliations

aClinical Trials Center and bDepartment of Dermatology, University Hospital Zurich, Zurich, and cLoewenpraxis, Lucerne, Switzerland

Related Articles for ""

Int Arch Allergy Immunol 2013;160:86–92

Do you have an account?

Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 31, 2011
Accepted: April 18, 2012
Published online: September 01, 2012
Issue release date: December 2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 8

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: Venom immunotherapy is highly efficacious in preventing anaphylactic sting reactions. However, there is an ongoing discussion regarding patient selection and whether and how to apply a cost-benefit analysis of venom immunotherapy. In order to help decision-making, we investigated the re-sting frequency of hymenoptera-venom-allergic patients to single out those at high risk. Methods: In this retrospective study, re-sting data of 96 bee-venom-allergic patients and 95 vespid-venom-allergic patients living mainly in a rural area of Switzerland were analyzed. Hymenoptera venom allergy status was rated according to the classification system of H.L. Mueller [J Asthma Res 1966;3:331–333]. Different risk-groups were defined according to sting exposure and their median sting-free interval was calculated. Results: The risk factors for a wasp or bee re-sting were outdoor occupation, beekeeping and habitation close to a bee-house. Half of all vespid-venom-allergic outdoor workers were re-stung within 3.75 years compared to 7.5 years for indoor workers. Similarly, 50% of the bee-venom-allergic beekeepers or subjects with a bee-house in the vicinity suffered a bee re-sting within 5.25 years compared to 10.75 years for individuals who were not beekeepers. Conclusions: The high degree of exposure of vespid-venom-allergic outdoor workers and bee-venom-allergic beekeepers and subjects living close to bee-houses underlines the high benefit of venom immunotherapy for these patients even if they suffered a non-life-threatening grade II reaction. Yet, bee-venom-allergic individuals with no proximity to bee-houses and with an indoor occupation face a very low exposure risk, which justifies epinephrine rescue treatment for these patients especially if they have suffered from grade II sting reactions.

© 2012 S. Karger AG, Basel


References

  1. Biló BM, Bonifazi F: Epidemiology of insect-venom anaphylaxis. Curr Opin Allergy Clin Immunol 2008;8:330–337.
  2. Moffitt JE, Golden DB, Reisman RE, Lee R, Nicklas R, Freeman T, Deshazo R, Tracy J, Bernstein IL, Blessing-Moore J, Khan DA, Lang DM, Portnoy JM, Schuller DE, Spector SL, Tilles SA: Stinging insect hypersensitivity: a practice parameter update. J Allergy Clin Immunol 2004;114:869–886.
  3. Bonifazi F, Jutel M, Biló BM, Birnbaum J, Müller U: Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice. Allergy 2005;60:1459–1470.
  4. Demain JG, Minaei AA, Tracy JM: Anaphylaxis and insect allergy. Curr Opin Allergy Clin Immunol 2010;10:318–322.
    External Resources
  5. Ross RN, Nelson HS, Finegold I: Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis. Clin Ther 2000;22:351–358.
  6. Przybilla B, Rueff F, Walker A, Räwer HC, Aberer W, Bauer CP, Berdel D, Biedermann T, Brockow K, Forster J, Fuchs T, Hamelmann E, Jakob T, Jarisch R, Merk HF, Müller U, Ott H, Sitter W, Urbanek R, Wedi B: Diagnose und Therapie der Bienen und Wespengiftallergie. Allergo J 2011;20:318.
  7. Oude Elberink JN, De Monchy JG, Van Der Heide S, Guyatt GH, Dubois AE: Venom immunotherapy improves health-related quality of life in patients allergic to yellow jacket venom. J Allergy Clin Immunol 2002;110:174–182.
  8. Oude Elberink JN, Dubois AE: Quality of life in insect venom allergic patients. Curr Opin Allergy Clin Immunol 2003;3:287–293.
  9. Przybilla B, Ruëff F: Hymenoptera venom allergy. J Dtsch Dermatol Ges 2010;8:114–127.
    External Resources
  10. Mosbech H, Müller U: Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. European Academy of Allergology and Clinical Immunology. Allergy 2000;55:1005–1010.
  11. More DR, Hagan LL: Factors affecting compliance with allergen immunotherapy at a military medical center. Ann Allergy Asthma Immunol 2002;88:391–394.
  12. Haye R, Dosen LK: Insect sting allergy. A study from 1980 to 2003 of patients who started treatment with venom immunotherapy between 1980 and 1998. Clin Mol Allergy 2005;3:12.
    External Resources
  13. Müller UR: Hymenoptera venom hypersensitivity: an update. Clin Exp Allergy 1998;28:4–6.
  14. Finegold I: Issues in stinging insect allergy immunotherapy: a review. Curr Opin Allergy Clin Immunol 2008;8:343–347.
  15. Mueller HL: Diagnosis and treatment of insect sensitivity. J Asthma Res 1966;3:331–333.
  16. Krishna MT, Ewan PW, Diwakar L, Durham SR, Frew AJ, Leech SC, Nasser SM: Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines. Clin Exp Allergy 2011;41:1201–1220.
  17. Golden DB: Insect sting allergy and venom immunotherapy: a model and a mystery. J Allergy Clin Immunol 2005;115:439–447.
  18. Müller UR: Insect Sting Allergy. Stuttgart, Gustav Fischer, 1990.
  19. Biló BM, Ruëff F, Mosbech H, Bonifazi F, Oude-Elberink JN: Diagnosis of hymenoptera venom allergy. Allergy 2005;60:1339–1349.
  20. Pérez-Pimiento A, Prieto-Lastra L, Rodríguez-Cabreros M, Reaño-Martos M, García-Cubero A, García-Loria J: Work-related anaphylaxis to wasp sting. Occup Med 2007;57:602–604.
    External Resources
  21. Bonadonna P, Schiappoli M, Dama A, Olivieri M, Perbellini L, Senna G, Passalacqua G: Is hymenoptera venom allergy an occupational disease? Occup Environ Med 2008;65:217–218.
  22. Ruëff F, Chatelain R, Przybilla B: Management of occupational hymenoptera allergy. Curr Opin Allergy Clin Immunol 2011;11:69–74.
    External Resources
  23. Müller UR: Bee venom allergy in beekeepers and their family members. Curr Opin Allergy Clin Immunol 2005;5:343–347.
    External Resources
  24. Oude Elberink JN, van der Heide S, Guyatt GH, Dubois AE: Analysis of the burden of treatment in patients receiving an epipen for yellow jacket anaphylaxis. J Allergy Clin Immunol 2006;118:699–704.
    External Resources
  25. Biló MB, Bonifazi F: The natural history and epidemiology of insect venom allergy: clinical implications. Clin Exp Allergy 2009;39:1467–1476.
  26. Ruëff F, Przybilla B, Biló MB, Müller U, Scheipl F, Aberer W, Birnbaum J, Bodzenta-Lukaszyk A, Bonifazi F, Bucher C, Campi P, Darsow U, Egger C, Haeberli G, Hawranek T, Korner M, Kucharewicz I, Kuchenhoff H, Lang R, Quercia O, Reider N, Severino M, Sticherling M, Sturm GJ, Wüthrich B: Predictors of severe systemic anaphylactic reactions in patients with hymenoptera venom allergy: importance of baseline serum tryptase-A study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J Allergy Clin Immunol 2009;124:1047–1054.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 31, 2011
Accepted: April 18, 2012
Published online: September 01, 2012
Issue release date: December 2012

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 8

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.