Original Research Article
Neuropsychiatric Symptoms in Mild Dementia with Lewy Bodies and Alzheimer’s DiseaseBjoerke-Bertheussen J.a · Ehrt U.a,c · Rongve A.b · Ballard C.d · Aarsland D.a
aDepartment of Psychiatry, Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, and bDepartment of Psychiatry, Haugesund Hospital, Haugesund, Norway; cGeriatric Psychiatric Department, Salus gGmbH Psychiatric Hospital, Bernburg, Germany; dWolfson Centre for Age-Related Diseases, King’s College London, London, UK
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Background/Aims: To compare neuropsychiatric symptoms in patients with Alzheimer’s disease (AD) and dementia with Lewy bodies(DLB). Methods: Neuropsychiatric symptoms and caregiver distress were assessed using the Neuropsychiatric Inventory (NPI) in mild DLB (n = 57) and AD (n = 126), and compared across the two groups using non-parametric tests. Results: The DLB patients had a higher NPI totalscore (median 24 vs. 11.5, p < 0.005), more numerous symptoms (median 5 vs. 4, p = 0.001) and more clinically significant symptoms (3 vs. 1, p = 0.001). They also had higher item hallucinations (6 vs. 2, p < 0.005) and apathy (7 vs. 5, p = 0.002) subscores. Caregivers scored higher on the NPI total caregiver distress scale (12.5 vs. 6, p = 0.003). Conclusions: In mild dementia, DLB patients have more neuropsychiatric symptoms and more associated caregiver distress compared with AD.
© 2012 S. Karger AG, Basel
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