Review Article · Übersichtsarbeit
Potential Use of Vaccines in the Primary Prevention of Breast Cancer in High-Risk PatientsLazzeroni M. · Serrano D.
Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy
Matteo Lazzeroni, MD
Division of Cancer Prevention and Genetics
European Institute of Oncology
Via Ripamonti 435, Milan, Italy
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Cancer vaccines are an emerging therapeutic and prophylactic modality that may play a more important role in cancer prevention and treatment in the future. Therapeutic cancer vaccines are designed to generate a targeted, immune-mediated antitumor response. Successful prophylactic vaccines are those against oncogenic viral infections, such as the human papillomavirus and cervical cancer. However, a tough challenge for the majority of tumor vaccines is the self-nature of tumor antigens. Ongoing studies are investigating methods to enhance vaccine strategies including immune-modulating agents. The present review analyzes the potential use of vaccines in the primary prevention of breast cancer, focusing on the recent extension of vaccine target selection to self-proteins that are overexpressed during the early stages of tumor development but whose expression no longer occurs as we age, a feature that may avoid clinically significant autoimmune sequelae.
© 2012 S. Karger AG, Basel
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