Neonatology

Original Paper

Poor Zinc Status in Early Infancy among Both Low and Normal Birth Weight Infants and Their Mothers in Delhi

Agarwal R.a · Virmani D.c · Jaipal M.b · Gupta S.a · Sankar M.J.a · Bhatia S.c · Agarwal A.b · Devgan V.b · Deorari A.a · Paul V.K.a · Toteja G.S.d · and Investigators of the LBW Micronutrient Study Group

Author affiliations

aDepartment of Pediatrics, All India Institute of Medical Sciences (AIIMS), bDepartment of Pediatrics, Swami Dayanand Hospital, cDepartment of Pediatrics, Kasturba Hospital, and dCentre for Promotion of Nutrition Research and Training with Special Focus on North-East, Tribal and Inaccessible Population, Indian Council of Medical Research (ICMR), Delhi, India

Keywords: ZincLow birth weightEarly infancy

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Neonatology 2013;103:54–59
https://doi.org/10.1159/000342227

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 15, 2012
Accepted: July 28, 2012
Published online: October 31, 2012
Issue release date: December 2012

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Low birth weight (LBW) infants are at high risk of zinc deficiency, but there is a paucity of data on their zinc status. Objective: To evaluate zinc status of LBW (BW <2,500 g) and normal birth weight (NBW; BW ≥2,500 g) infants at birth and in early infancy. Methods: A total of 339 infants (LBW, n = 220; NBW, n = 119) were enrolled, and venous blood samples of mother-infant dyad were taken within 48 h of birth. Infants’ levels were repeated between 2 and 10 months of age. Serum zinc levels were estimated using an inductively coupled plasma mass spectrometer. Primary outcome was zinc deficiency, defined as serum zinc <65 µg/dl. Results: Zinc results were available for 182 LBW and 103 NBW infants at birth and for 100 LBW and 66 NBW infants at follow-up with a median postnatal age of 14 and 15.5 weeks, respectively. Median zinc levels were low and comparable at birth as well as at follow-up, with zinc deficiency being present in 51.0% of LBW and 42.4% of NBW infants at birth and in 79.0% of LBW and 66.7% of NBW infants at follow-up. Zinc levels decreased significantly in both groups from birth to follow-up, irrespective of zinc multivitamin supplementation. Zinc levels of infants with BW <2,000 g at follow-up were significantly lower compared to infants with higher BW. Conclusion: Zinc status was poor in many infants at birth irrespective of BW. Zinc status worsened significantly during early infancy, with infants with BW <2,000 g having the lowest zinc levels.

© 2012 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 15, 2012
Accepted: July 28, 2012
Published online: October 31, 2012
Issue release date: December 2012

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

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2013, Vol.103, No. 1

December 2012

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