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Special Situations

Continuous Hemodiafiltration with a Cytokine-Adsorbing Hemofilter for Sepsis

Hirasawa H.a · Oda S.a · Nakamura M.a · Watanabe E.a · Shiga H.b · Matsuda K.c

Author affiliations

aDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, bDepartment of Emergency and Critical Care Medicine, Teikyo University Chiba Medical Center, Chiba, and cDepartment of Emergency and Critical Care Medicine, Yamanashi University School of Medicine, Yamanashi, Japan

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Blood Purif 2012;34:164–170

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Article / Publication Details

First-Page Preview
Abstract of Special Situations

Published online: October 24, 2012
Issue release date: October 2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

Abstract

Since the introduction of the new pathophysiological concept of pathogen-associated molecular patterns (PAMPS) and alarmins, endotoxin has been recognized as only one of the PAMPS. It is widely accepted that hypercytokinemia plays a pivotal role in the pathophysiology of sepsis. Many kinds of blood purification modalities have been proposed as a therapeutic tool against sepsis, including high-volume continuous hemofiltration whose efficacy has recently been questioned. We report that continuous hemodiafiltration (CHDF) with a cytokine-adsorbing hemofilter (CAH), such as polymethyl methacrylate hemofilter and AN69ST hemofilter (CAH-CHDF), can remove many kinds of cytokines and has been very effective in the treatment of severe sepsis and septic shock. Based on the understanding of the recent pathophysiology, we suggest that CAH-CHDF is an alternate therapy to direct hemoperfusion with endotoxin-adsorbing column in the treatment of sepsis.

© 2012 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Special Situations

Published online: October 24, 2012
Issue release date: October 2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU


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