International Archives of Allergy and Immunology

Original Paper

Serum Total Immunoglobulin E Is a Surrogate of Atopy in Adult-Onset Asthma: A Longitudinal Study

Carsin A.-E.a–c · Zock J.-P.a–c · Jarvis D.e · Basagaña X.a–c · Heinrich J.f · Toren K.g · Janson C.h · Anto J.M.a–d · Sunyer J.a–d

Author affiliations

aCentre for Research in Environmental Epidemiology, bHospital del Mar Research Institute, cCIBER Epidemiología y Salud Pública, and dUniversitat Pompeu Fabra, Barcelona, Spain; eRespiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College, London, UK; fInstitute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environment and Health, Neuherberg, Germany; gSection of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, and hDepartment of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden

Keywords: Adult asthmaAtopyTotal immunoglobulin E

Related Articles for ""
Int Arch Allergy Immunol 2013;160:387–392
https://doi.org/10.1159/000342464

Log in to MyKarger to check if you already have access to this content.




Forgot your password
Sign up to MyKarger

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more
CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates

Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 19, 2012
Accepted: July 30, 2012
Published online: November 23, 2012
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific IgEs and new-onset asthma using longitudinal data from the European Community Respiratory Health Survey. Methods: Serum total and specific IgE to 4 common inhalant allergens were measured at baseline in 9,175 participants, with a follow-up of 9 years. Individuals with asthma history and/or asthma symptoms were excluded. Atopy was defined as the presence of at least one specific IgE ≥0.35 kU/l. Total and specific IgEs were regressed against new-onset asthma using multivariate logistic regression with a random intercept for the study centre. Results: Two hundred and ninety-seven participants had developed asthma during follow-up (incidence rate 5.7 per 1,000 person-years). A 10% higher level of total IgE was associated with a 12% increased risk of new-onset asthma (p = 0.005). However, after adjustment for the number of positive specific IgEs [odds ratio (OR) for multiple sensitization 1.74, 95% confidence interval (CI) 1.05–2.88] and the sum of allergen-specific IgEs (OR 1.18, 95% CI 1.00–1.40), the association between total IgE and asthma disappeared (OR 1.00, 95% CI 0.91–1.10). Seventeen percent of new-onset asthma cases could be attributed to atopy, and this estimate was not largely modified when the total IgE level was simultaneously taken into account. Conclusions: After taking into account the number and intensity of 4 specific IgEs, the serum total IgE level was not associated with new-onset asthma in adults.

© 2012 S. Karger AG, Basel



Related Articles:

References

  1. Pearce N, Pekkanen J, Beasley R: How much asthma is really attributable to atopy? Thorax 1999;54:268–272.
    External Resources
  2. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD: Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991;325:1067–1071.
    External Resources
  3. Schäfer T, Wölke G, Ring J, Wichmann HE, Heinrich J: Allergic sensitization to cat in childhood as major predictor of incident respiratory allergy in young adults. Allergy 2007;62:1282–1287.
    External Resources
  4. Jackola DR, Blumenthal MN, Rosenberg A: Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE. Hum Immunol 2004;65:20–30.
    External Resources
  5. Beeh KM, Ksoll M, Buhl R: Elevation of total serum immunoglobulin E is associated with asthma in nonallergic individuals. Eur Respir J 2000;16:609–614.
    External Resources
  6. Sunyer J, Antó JM, Castellsagué J, Soriano JB, Roca J: Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. Eur Respir J 1996;9:1880–1884.
    External Resources
  7. Gergen PJ, Arbes SJ, Calatroni A, Mitchell HE, Zeldin DC: Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol 2009;124:447–453.
    External Resources
  8. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG: Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271–277.
    External Resources
  9. Marsh DG, Bias WB, Ishizaka K: Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci USA 1974;71:3588–3592.
    External Resources
  10. Marsh DG, Chase GA, Freidhoff LR, Meyers DA, Bias WB: Association of HLA antigens and total serum immunoglobulin E level with allergic response and failure to respond to ragweed allergen Ra3. Proc Natl Acad Sci USA 1979;76:2903–2907.
    External Resources
  11. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH: Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152–1156.
    External Resources
  12. Burney PG, Newson RB, Burrows MS, Wheeler DM: The effects of allergens in outdoor air on both atopic and nonatopic subjects with airway disease. Allergy 2008;63:542–546.
    External Resources
  13. Antó JM, Sunyer J, Basagaña X, Garcia-Esteban R, Cerveri I, de Marco R, et al: Risk factors of new-onset asthma in adults: a population-based international cohort study. Allergy 2010;65:1021–1030.
    External Resources
  14. Burney PGJ, Luczynska C, Chinn S, Jarvis D: The European Community Respiratory Health Survey. Eur Respir J 1994;7:954–960.
    External Resources
  15. Burney P, Malmberg E, Chinn S, Jarvis D, Luczynska C, Lai E: The distribution of total and specific serum IgE in the European Community Respiratory Health Survey. J Allergy Clin Immunol 1997;99:314–322.
    External Resources
  16. Greenland S, Drescher K: Maximum likelihood estimation of the attributable fraction from logistic models. Biometrics 1993;49:865–872.
    External Resources
  17. Jarvis D, Chinn S, Luczynska C, Burney P: The association of smoking with sensitization to common environmental allergens: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;104:934–940.
    External Resources
  18. Subbarao P, Mandhane PJ, Sears MR: Asthma: epidemiology, etiology and risk factors. CMAJ 2009;181:E181–E190.
    External Resources
  19. Burrows B, Martinez FD, Cline MG, Lebowitz MD: The relationship between parental and children’s serum IgE and asthma. Am J Respir Crit Care Med 1995;152:1497–1500.
    External Resources
  20. Sparrow D, O’Connor GT, Basner RC, Rosner B, Weiss ST: Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study. Am Rev Respir Dis 1993;147:367–371.
    External Resources
  21. Bodner CH, Ross S, Little J, Douglas JG, Legge JS, Friend JA,et al: Risk factors for adult onset wheeze: a case control study. Am J Respir Crit Care Med 1998;157:35–42.
    External Resources
  22. Jaakkola MS, Ieromnimon A, Jaakkola JJ: Are atopy and specific IgE to mites and molds important for adult asthma? J Allergy Clin Immunol 2006;117:642–648.
    External Resources
  23. Peat JK, Toelle BG, Dermand J, van den Berg R, Britton WJ, Woolcock AJ: Serum IgE levels, atopy, and asthma in young adults: results from a longitudinal cohort study. Allergy 1996;51:804–810.
    External Resources
  24. Malo JL, L’Archeveque J, Castellanos L, Lavoie K, Ghezzo H, Maghni K: Long-term outcomes of acute irritant-induced asthma. Am J Respir Crit Care Med 2009;179:923–928.
    External Resources
  25. Wang TN, Lin MC, Wu CC, Leung SY, Huang MS, Chuang HY, Lee CH, Wu DC, Ho PS, Ko AM, Chang PY, Ko YC: Risks of exposure to occupational asthmogens in atopic and nonatopic asthma: a case-control study in Taiwan. Am J Respir Crit Care Med 2010;182:1369–1376.
    External Resources
  26. Kogevinas M, Zock JP, Jarvis D, Kromhout H, Lillienberg L, Plana E, Radon K, Toren K, Alliksoo A, Benke G, et al: Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II). Lancet 2007;370:336–341.
    External Resources
  27. Bousquet PJ, Hooper R, Kogevinas M, Jarvis D, Burney P: Number of allergens to be tested to assess allergenic sensitization in epidemiologic studies: results of the European Community Respiratory Health Survey I. Clin Exp Allergy 2007;37:780–787.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 19, 2012
Accepted: July 30, 2012
Published online: November 23, 2012
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Article Tools
Article Details

2013, Vol.160, No. 4

March 2013

Free Supplementary Material

Article

Recommend This
TOP