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Environment and ‘In-Vironment’

Microparticles and Their Impact on Intestinal Immunity

Becker H.M.a · Bertschinger M.M.b · Rogler G.b

Author affiliations

aDepartment of Medicine, University of Calgary, Calgary, Alta., Canada; bDivision of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland

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Dig Dis 2012;30(suppl 3):47–54

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Article / Publication Details

First-Page Preview
Abstract of Environment and ‘In-Vironment’

Published online: January 03, 2013
Issue release date: January 2013

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI

Abstract

Microparticles are small (<1 µm), nonbiological particles that are used in many areas of daily life. As food additive they are used as anticaking agents or food colorants. The most common food-derived ingested compounds are aluminium silicate and titanium dioxide (TiO2), the latter being a white pigment used in toothpaste or sugar toppings. The increasing abundance of microparticles in the Western diet raises the question of the potential risks associated with gastrointestinal diseases such as Crohn’s disease (CD). Accumulation of particles has been shown in cells of Peyer’s patches, but it is not clear whether this also has pathological effects. NLRP3 is a member of the intracellular pattern recognition receptor family and it is part of the inflammasome, a multiprotein complex containing caspase-1 which activates the proinflammatory cytokines interleukin (IL)-1β and IL-18. With regard to recent findings identifying small particles such as asbestos and monosodium urate as NLRP3 activators, TiO2 may be another potential target for inflammasome studies. We found that macrophage-like cells readily take up TiO2 after 6 h. Incubation of cells with TiO2 resulted in the assembly of NLRP3 with caspase-1. This inflammasome assembly correlated with secretion of IL-1β. In intestinal epithelial cells, TiO2 also was found to be ingested. The counting of particles localized intracellularly revealed a dose-dependent increase of TiO2-positive cells. This points to the fact that in humans with a leaky intestinal barrier (such as IBD patients), TiO2 microparticles may be taken up by macrophages and intestinal epithelial cells, may activate the inflammasome and induce IL-1β and IL-18 secretion. This may aggravate inflammation in susceptible individuals.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Environment and ‘In-Vironment’

Published online: January 03, 2013
Issue release date: January 2013

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


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